文献类型：期刊文献

英文题名：Polysaccharide conjugate vaccine: A kind of vaccine with great development potential

作者：Zhao, Jing[1,2];Hu, Gang[5,6];Huang, Yi[6,7];Huang, Yingchun[4];Wei, Xin[3];Shi, Jianyou[1,2]

第一作者：Zhao, Jing

通讯作者：Shi, JY[1];Shi, JY[2];Wei, X[3];Huang, YC[4]

机构：[1]Univ Elect Sci & Technol China, Sichuan Acad Med Sci, Dept Pharm, Chengdu 610072, Peoples R China;[2]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Personalized Drug Therapy Key Lab Sichuan Prov, Chengdu 610072, Peoples R China;[3]Chengdu Kanghua Biol Prod Co Ltd, Chengdu 610100, Peoples R China;[4]Beijing Union Univ, Coll Biochem Engn, Beijing 100023, Peoples R China;[5]Univ Elect Sci & Technol China, Sichuan Acad Med Sci, Galactophore Dept, Chengdu 610072, Peoples R China;[6]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Chengdu 610072, Peoples R China;[7]Univ Elect Sci & Technol China, Sichuan Acad Med Sci, Clin Lab, Chengdu 610072, Peoples R China

第一机构：Univ Elect Sci & Technol China, Sichuan Acad Med Sci, Dept Pharm, Chengdu 610072, Peoples R China

通讯机构：[1]corresponding author), Univ Elect Sci & Technol China, Sichuan Acad Med Sci, Dept Pharm, Chengdu 610072, Peoples R China;[2]corresponding author), Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Personalized Drug Therapy Key Lab Sichuan Prov, Chengdu 610072, Peoples R China;[3]corresponding author), Chengdu Kanghua Biol Prod Co Ltd, Chengdu 610100, Peoples R China;[4]corresponding author), Beijing Union Univ, Coll Biochem Engn, Beijing 100023, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：2021

卷号：32

期号：4

起止页码：1331-1340

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;Scopus(收录号：2-s2.0-85093982332);WOS:【SCI-EXPANDED(收录号:WOS:000644739300006)】；

基金：This work is funded by National Natural Science Foundation of China (No. 82073311), Key Research Development Program of Science and Technology Department of Sichuan Provincial (No. 2019YFS0514), National Natural Science Foundation of China (No. 81741100), the Natural Science Foundation of Beijing, China (No. 6181001), National Key Research and Development Program of China (No. 2020YFC2005500), Key Research and Development Program of Science and Technology Department of Sichuan Province (No. 2019YFS0514) and The Major Science and Technology R & G Program of Jiangxi Province (No. 20194ABC28007).

语种：英文

外文关键词：Streptococcus pneumoniae; Neisseria meningitides; Protein carriers; Coupling chemistry; Quality control; Haemophilus influenzae type b (Hib)

摘要：Diseases caused by microbial bacteria such as Haemophilus influenzae type b (Hib), Streptococcus pneumoniae and Neisseria meningitidis are still very serious disease, which has brought a lot of burden to many countries. Development of vaccine has brought hope for the prevention of such diseases. Polysaccharide conjugate vaccines have been shown to have very good effects in preventing such diseases. The polysaccharide conjugate vaccine adds the positive characteristics of protein antigens to the polysaccharide antigen, thereby improving the immunogenicity of the polysaccharide antigen, solving the problem that the polysaccharide vaccine cannot be effectively applicated in toddler or children, which greatly promoting the development of this vaccine. This review introduces the progress of polysaccharide conjugate vaccines. We introduce the typical polysaccharide conjugate vaccines currently on the market firstly, and then elucidate the protein carriers, the coupling chemistry methods and quality control that required in the preparation of polysaccharide conjugate vaccines. We can see that polysaccharide conjugate vaccine is a kind of vaccine with great development potential, which can be a sharp edge for us to prevent diseases. ? 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.