文献类型：期刊文献

英文题名：Research progress on speciation analysis of arsenic in traditional Chinese medicine

作者：Peng, Congnan[1];Zhou, Juntong[1];Li, Chi[2];Chen, Yuxin[1];Huo, Qing[1];Xie, Fei[1]

第一作者：Peng, Congnan

通讯作者：Huo, Q[1];Xie, F[1]

机构：[1]Beijing Union Univ, Dept Biomed, Biochem Engn Coll, Beijing 100023, Peoples R China;[2]Beijing City Univ, Dept Chinese Med, Beijing 100083, Peoples R China

第一机构：北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Dept Biomed, Biochem Engn Coll, Beijing 100023, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：2022

卷号：20

期号：1

起止页码：23-39

外文期刊名：OPEN CHEMISTRY

收录：;Scopus(收录号：2-s2.0-85124661631);WOS:【SCI-EXPANDED(收录号:WOS:000749463900001)】；

基金：This research was financially supported by the National Natural Science Foundation of China (Grant No. 11975048) and Beijing Union University Graduate Program (Grant No. YZ2020K001).

语种：英文

外文关键词：traditional Chinese medicine; arsenic; speciation analysis; research progress

摘要：Traditional Chinese medicine contains arsenic (As), which in the natural environment accumulates in plants during the growth of Chinese medicinal materials; there are mineral medicines containing As in Chinese patent medicine such as As4S4, As2S3, etc. Due to the toxicity of As-containing compounds and its role in inflammation and treatment of cancers such as leukemia, it is necessary to analyze the chemical form of As. A comprehensive investigation of the compound forms of heavy metals rather than the simple total amount of elements will lay the foundation for the scientific and objective evaluation of the safety of heavy metals. This article summarizes the speciation of As in bulk Chinese medicinal materials and Chinese patent medicines in recent years, and reviews the main research methods of As speciation analysis. The separation and detection combined analysis method focuses on the high-performance liquid chromatography-plasma mass spectrometry and high-performance liquid chromatography-hydride generation-atomic fluorescence spectroscopy, etc. Taking the advanced synchrotron radiation source as the research platform, the use of X-ray near edge absorption fine structure spectrum and micro-area X-ray fluorescence analysis as a microscopic analysis technique supports direct analysis of the As speciation in situ. It is the most promising morphological analysis method.