文献类型：期刊文献

英文题名：The associations between plasma phytoestrogens concentration and metabolic syndrome risks in Chinese population

作者：Liu, Jie[1];Mi, Shengquan[2];Du, Li[3];Li, Xiang[1];Jia, Keyu[1];Zhao, Jing[1];Zhang, Hong[1,3];Zhao, Wenhua[4];Gao, Ying[1]

第一作者：Liu, Jie

通讯作者：Gao, Y[1];Zhao, WH[2]

机构：[1]Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai, Peoples R China;[2]Beijing Union Univ, Coll Biochem Engn, Beijing, Peoples R China;[3]Fudan Univ, Inst Biostat, Sch Life Sci, Shanghai, Peoples R China;[4]Chinese Ctr Dis Control & Prevent, Natl Inst Nutr & Hlth, Beijing, Peoples R China

第一机构：Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai, Peoples R China

通讯机构：[1]corresponding author), Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai, Peoples R China;[2]corresponding author), Chinese Ctr Dis Control & Prevent, Natl Inst Nutr & Hlth, Beijing, Peoples R China.

年份：2018

卷号：13

期号：3

外文期刊名：PLOS ONE

收录：;Scopus(收录号：2-s2.0-85044173652);WOS:【SCI-EXPANDED(收录号:WOS:000427901500047)】；

基金：This work was supported by the National Key Research and Development Plan (2016YFD0400200 YG) and the 100 Talented Plan of Chinese Academy of Sciences (YG).

语种：英文

摘要：Metabolic syndrome (MetS) has become an important issue in the healthcare systems of both developed and developing countries. Phytoestrogens have shown estrogenic effects, which may involve in the etiology of MetS. The current study consisted of 293 MetS cases and 264 healthy controls. The concentrations of seven plasma phytoestrogens (daidzein, genistein, glycitein, equol, enterolactone, enterodiol and coumestrol) were detected by UPLC-MS/MS. Adjusted unconditional logistic regression was used to assess the associations between plasma phytoestrogens concentration and risks of MetS, as well as the associations between plasma phytoestrogens concentration and MetS components. Linear regression was used to evaluate the associations between equol concentration in equol-producers and MetS components. Higher concentrations of total isoflavone and equol were associated with decreased risk of MetS. The equol concentration was negatively associated with waist circumference and positively associated with HDL-C level. Increased daidzein was associated with both lower waist circumference and lower fasting blood glucose levels. Our results suggested that higher plasma total isoflavone, equol and daidzein might decrease MetS risk.