文献类型：期刊文献

中文题名：美洛昔康脂质体凝胶剂的研制与质量评价

英文题名：Preparation and Quality Evaluation of Liposomal Gel of Meloxicam

作者：冯淑华[1];李可意[1];张彦文[2];李娟[1]

第一作者：冯淑华

机构：[1]北京联合大学生物化工学院,北京100023;[2]天津医科大学药学院,天津300070

第一机构：北京联合大学生物化学工程学院

年份：2008

卷号：25

期号：2

起止页码：122-125

中文期刊名：中国现代应用药学

外文期刊名：Chinese Journal of Modern Applied Pharmacy

收录：CSTPCD;;北大核心:【北大核心2004】；CSCD:【CSCD_E2011_2012】；

语种：中文

中文关键词：美洛昔康;脂质体凝胶;质量评价

外文关键词：meloxicam ; liposoinal gel ; preparation ; characterization

摘要：目的制备含有美洛昔康的脂质体凝胶,并进行质量初步评价。方法用正交设计优选该脂质体的处方及制备工艺,并用扫描电镜观测其外观、大小及分布,用微型凝胶柱测定其包封率,并进一步制备成凝胶,初步考察该制剂的稳定性。结果所得脂质体外观圆整,分布较均匀,平均包封率(67.8±1.2)%(n=3),所得凝胶剂为半透明黏稠状胶体,稳定性良好。结论该脂质体凝胶制备工艺可行,具有开发价值。
OBJECTIVE To prepare liposmal gel of meloxicam, and evaluate its physico-chemical properties. METHODS The optimum composition and preparation process of the liposome was selected with orthogonal design. The shape, size and size distribution were observed by scanning electron microscopy. The drug encapsulation efficiency was determined by GC. The gel was then prepared based on the liposome, and the stability of the formulation was also observed preliminarily. RESULTS The obtained liposome had a sphere shape with narrow size distribution, and higher encapsulation efficiency （67.8 ± 1.2% ）. The prepared gel is semitransparent and melicera with good stability. CONCLUSION The preparation method of meloxicam liposomal gel is valuable to be further investigated.