文献类型：期刊文献

英文题名：Cooked highland red rice ameliorates diabetic symptoms via gut microbiota-metabolite interactions in streptozotocin-induced mice

作者：Li, Zuming[1];Zhao, Leyi[1];Wang, Liyuan[1];Shao, Xinyu[1];Cheng, Ziqing[1];Si, Shiquan[3];Yang, Xuhua[3];She, Yongxin[4];Yang, Xiaomeng[2];Zhang, Michael[5];Shen, Peixuan[1];Yan, Xikun[1];Zeng, Yawen[2];Li, Xia[2]

第一作者：李祖明

通讯作者：Zeng, YW[1];Li, X[1]

机构：[1]Beijing Union Univ, Coll Biochem Engn, Beijing 100023, Peoples R China;[2]Yunnan Acad Agr Sci, Biotechnol & Germplasm Resources Inst, Kunming 650205, Peoples R China;[3]Lijiang Ninglang Yikang Agr Prod Dev Co Ltd, Lijiang 674309, Peoples R China;[4]Chinese Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, State Key Lab Qual & Safety Agroprod, Beijing 100081, Peoples R China;[5]Univ Manitoba, Dept Phys & Astron, Winnipeg, MB R3T 2N2, Canada

第一机构：北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Yunnan Acad Agr Sci, Biotechnol & Germplasm Resources Inst, Kunming 650205, Peoples R China.

年份：2026

卷号：136

外文期刊名：JOURNAL OF FUNCTIONAL FOODS

收录：;Scopus(收录号：2-s2.0-105026409588);WOS:【SCI-EXPANDED(收录号:WOS:001662639600001)】；

基金：This work was supported by the National Natural Science Foundation of China (No. 31760376) ; National Key Assistance County Cluster Assistance Project of Lijiang Science and Technology Bureau (2022LJZTBF001) ; 'Qimingxing' Science and Technology Innovation Project Fund (20051055) and Lijiang Ninglang Yikang Agricultural Products Development Co., Ltd. Cooperation Project (50304JA2337) .

语种：英文

外文关键词：Highland red Rice; Diabetes mellitus; Gut microbiota; Intestinal metabolites

摘要：Highland red rice is nutrient-rich due to its unique geographical location. However, systematic studies examining its antidiabetic effects and the underlying mechanisms are limited. In this study, cooked highland red rice (CHRR) was incorporated into a specialized feed and used as a dietary intervention in streptozotocin (STZ)induced diabetic mice. CHRR intervention significantly reduced hyperglycemia, improved lipid dysregulation, alleviated hepatic oxidative stress, and restored pancreatic beta-cell function. Furthermore, CHRR markedly increased the relative abundances of beneficial bacteria, including Dubosiella, Faecalibaculum, Romboutsia, and Turicibacter. These beneficial microbial communities facilitated favorable alterations in intestinal metabolites. Notably, CHRR significantly increased short-chain fatty acid (SCFA) levels and decreased nucleotide metabolites (e.g., xanthosine, xanthine, and inosine). Correlation analyses showed that Dubosiella and Faecalibaculum were negatively correlated with nucleotide metabolites, suggesting their potential roles in modulating nucleotide metabolism. In conclusion, these findings suggest that highland red rice may ameliorate diabetic symptoms through the modulation of gut microbiota composition and metabolite profiles, supporting its potential development as a functional food for diabetes management.