文献类型：期刊文献

英文题名：Triterpenoids from Ainsliaea yunnanensis Franch. and Their Biological Activities

作者：Li, Jinjie[1,2];Zhang, Bo[2];Liu, Hailing[1];Zhang, Xuan[1];Shang, Xiaoya[2];Zhao, Changqi[1]

第一作者：Li, Jinjie;李金杰

通讯作者：Zhao, CQ[1];Shang, XY[2]

机构：[1]Beijing Normal Univ, Coll Life Sci, Minist Educ, Key Lab Cell Proliferat & Regulat Biol, Beijing 100875, Peoples R China;[2]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China

第一机构：Beijing Normal Univ, Coll Life Sci, Minist Educ, Key Lab Cell Proliferat & Regulat Biol, Beijing 100875, Peoples R China

通讯机构：[1]corresponding author), Beijing Normal Univ, Coll Life Sci, Minist Educ, Key Lab Cell Proliferat & Regulat Biol, Beijing 100875, Peoples R China;[2]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2016

卷号：21

期号：11

外文期刊名：MOLECULES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000389918200063)】；

基金：We gratefully acknowledge financial support from the Beijing Natural Sciences Foundation (Grant No. 7142028); the National Natural Sciences Foundation of China (NNSFC; Grant No. 31171669); and the Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University (Zk60201601).

语种：英文

外文关键词：Ainsliaea yunnanensis; triterpenoids; NMR; structures; activity

摘要：One new pentacyclic triterpenoid, 3 beta-carboxylicfilic-4(23)-ene (1), and three known pentacyclic triterpenoids, adian-5-en-3 alpha-ol (2), fernenol (3), and fern-7-en-3 beta-ol (4) were isolated from the petroleum ether phase of the ethanolic extract of Ainsliaea yunnanensis Franch. Their structures were established by spectroscopic methods including 1-D and 2-D NMR, and MS experiments. Compounds 1, 2, 3, and 4 showed significant selective cytotoxicity against human acute monocytic leukemia cell line (THP-1) with IC50 values of 5.12 mu M, 1.78 mu M, 1.74 mu M, and 1.75 mu M, respectively. Compound 1 also showed an anti-inflammatory effect through the inhibition of the activity of NF-kappa B by blocking the nuclear translocation of p65.