文献类型：期刊文献

英文题名：Development of ligustrazine hydrochloride carboxymethyl chitosan and collagen microspheres: Formulation optimization, characterization, and vitro release

作者：Lin, Qiang[1];Huo, Qing[2];Qin, Yingzhe[1];Zhao, Zhuo[1];Tao, Fengyun[2]

通讯作者：Huo, Q[1]

机构：[1]Beijing Union Univ, Coll Art & Sci, Beijing, Peoples R China;[2]Beijing Union Univ, Biochem Engn Coll, Beijing, Peoples R China

第一机构：北京联合大学应用文理学院

通讯机构：[1]corresponding author), Beijing Union Univ, Biochem Engn Coll, Fac Biomed, Beijing 100023, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：2017

卷号：8

期号：1

起止页码：55-60

外文期刊名：BIOENGINEERED

收录：;Scopus(收录号：2-s2.0-84989221020);WOS:【SCI-EXPANDED(收录号:WOS:000391701100008)】；

基金：This work was supported by the topic of biologically active substances and functional food, Beijing Key Laboratory (ZK70201401), 2014 Beijing Natural Science Foundation - Beijing Institute of Science and Technology jointly funded by the projects L140006 and the National Natural Science Foundation of China (Grant No. 11475020).

语种：英文

外文关键词：carboxymethyl chitosan; collagen; ligustrazine hydrochloride; micro spheres

摘要：This study investigates the preparation of ligustrazine hydrochloride carboxymethyl chitosan and collagen microspheres. This experiment investigates effects of the ratio of carboxymethyl chitosan and collagen blend, water to oil ratio, stirring speed, and other factors on the microsphere properties. The experiment had the following conditions: a 1:2 proportion of carboxymethyl chitosan and collagen, a 1:2 proportion of drugs and materials, a 5:1 proportion of oil phase and water phase, 0.5% of span80, a 600 r/min stirring speed, 3ml of a cross-linking agent, 3h of cross-linking curing, 1.25 +/- 0.05 mm diameter LTH microcapsules, a 54.08% envelop rate, and a 14.16% carrier rate. The microspheres release rate reached 66% within 1 h, then steadily released within 5h in vitro. The experimental results showed that the ligustrazine hydrochloride microsphere production process was stable and exhibited a good release effect compared with other ligustrazine hydrochloride tablets and pills.