文献类型：期刊文献

英文题名：A new cytotoxic 12-membered macrolactone from the endophytic fungus Exserohilum rostratum LPC-001

作者：Lin, Peng-Cheng[1];Wu, Yu-Zhuo[2,3];Bao, Ting-Wen[1];Wang, Ya-Nan[2,3];Shang, Xiao-Ya[4];Lin, Sheng[1,2,3]

第一作者：Lin, Peng-Cheng

通讯作者：Lin, S[1];Lin, S[2];Lin, S[3];Shang, XY[4]

机构：[1]Qinghai Univ Nationalities, Coll Pharmaceut Sci, Xining 810000, Qinghai, Peoples R China;[2]Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China;[3]Peking Union Med Coll, Beijing 100050, Peoples R China;[4]Beijing Union Univ, Beiijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China

第一机构：Qinghai Univ Nationalities, Coll Pharmaceut Sci, Xining 810000, Qinghai, Peoples R China

通讯机构：[1]corresponding author), Qinghai Univ Nationalities, Coll Pharmaceut Sci, Xining 810000, Qinghai, Peoples R China;[2]corresponding author), Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China;[3]corresponding author), Peking Union Med Coll, Beijing 100050, Peoples R China;[4]corresponding author), Beijing Union Univ, Beiijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2018

卷号：20

期号：11

起止页码：1093-1100

外文期刊名：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000458315000011)】；

基金：This research was financially supported by the National Natural Science Foundation of China (NNSFC; Nos. 81522050, 81773589, 81760783), Key projects of the Beijing Natural Sciences Foundation and Beijing Municipal Education Committee (no. KZ201811417049), the Science and Technology program of Qinghai (no. 2018-ZJ-739), the National Science and Technology Project of China (no. 2018zx09711001-001), and the CAMS Innovation Fund for Medical Science (CIFMS; No. 2017-I2M-3-010).

语种：英文

外文关键词：Endophytic fungus; Exserohilum rostratum; oxacyclododecindione-type macrolactone; cytotoxicity

摘要：A new oxacyclododecindione-type macrolactone, (13R,14S,15R)-13-hydroxy-14-deoxyoxacyclododecindione (1), has been obtained from the solid cultures of the fungus Exserohilum rostratum, a fungal strain endophytic in Gymnadenia conopsea. Its structure, including the absolute configuration, was extensively established by 1D and 2D NMR data, the modified Mosher method, and a combination of experimental and theoretically calculated electronic circular dichroism (ECD) spectra. Compound 1 showed weak selective cytotoxicity against the A549 lung cell line with an IC50 value of 9.2 mu M.