文献类型：期刊文献

中文题名：益生菌与肠道菌群、免疫调节的相互作用与机制研究进展

英文题名：Interaction and Mechanism of Probiotics with Gut Flora and Immune Regulation: A Review

作者：唐曼玉[1];王晚晴[1,2];强敬雯[1];华威[1,2];武双[1,2];李亚丽[1];甄新[1];李春庚[1];程艳玲[1,2]

第一作者：唐曼玉

机构：[1]北京联合大学生物化学工程学院,北京100023;[2]生物质废弃物资源化利用北京市重点实验室,北京100023

第一机构：北京联合大学生物化学工程学院

年份：2022

卷号：43

期号：16

起止页码：486-493

中文期刊名：食品工业科技

外文期刊名：Science and Technology of Food Industry

收录：CSTPCD;;北大核心:【北大核心2020】；

基金：北京市教委科技计划项目(KM201711417001);北京市优秀人才培养项目(2018000020124G074);北京联合大学绿色校园专项(ZK50202101);北京联合大学研究生科研创新资助项目(YZ2020K001);北京联合大学科研项目(XP202004)。

语种：中文

中文关键词：益生菌;肠道菌群;益生菌与肠道互作;免疫调节;免疫机制

外文关键词：probiotics;intestinal flora;probiotic bacteria and intestinal interaction;immunomodulation;immunologic mechanism

摘要：益生菌在改善宿主肠道微生态平衡、提高宿主健康水平和健康状态等方面发挥有益作用。其主要通过调理肠道微生物群、参与多种疾病的免疫调节,从而改善胃肠道生理机能来影响宿主健康。益生菌在预防和治疗胃肠道疾病等方面具有相当大的潜力,需要对其与肠道菌群、免疫调节的相互作用机制更深入的了解。本文对益生菌在肠道的分布与定植、益生菌对肠道菌群和肠道功能的调控作用以及益生菌与免疫调节的关系做了简单论述,以期为今后益生菌与肠道菌群互作研究以及益生菌的临床应用提供参考。
Probiotics play beneficial roles in improving the host intestinal microecological balance and improving the host health level and health state. It mainly affects the host health by regulating the intestinal microbiota and participating in the immune regulation of various diseases, thus improving the gastrointestinal physiology. Probiotics have considerable potential in the prevention and treatment of gastrointestinal diseases, and a deeper understanding of the mechanisms of their interaction with gut flora and immune regulation are needed. In this paper, the distribution and colonization of probiotics in the intestinal tract, the regulation of probiotics on intestinal flora and intestinal function, and the relationship between probiotics and immune regulation are briefly discussed, in order to provide reference for the future research on the interaction between probiotics and intestinal flora and the clinical application of probiotics.