文献类型：期刊文献

英文题名：Norursane-type triterpenoids from Rosmarinus officinalis and their anti-inflammatory activity evaluation

作者：Zhou, Na[1];Wang, Ze-yu[1];Wu, Yong[1];Zhong, Xiang-jian[1];Wang, Xin[1];Li, Jin-jie[1];Shang, Xiao-ya[1]

第一作者：Zhou, Na

通讯作者：Li, JJ[1];Shang, XY[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2021

卷号：153

外文期刊名：FITOTERAPIA

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000684861800011)】；

基金：The authors gratefully acknowledgments grants from the Scientific Research Common Program of Beijing Municipal Commission of Education (Grant No. KM202011417014) and Beijing Natural Science Foundation (No. 7214280) .

语种：英文

外文关键词：Rosmarinus officinalis; Norursane-type triterpenoids; Anti-inflammatory activity

摘要：Five norursane-type triterpenoids, including three novel of 3 beta-28-norursa-12,17,19,21-tetraene-3-ol (1), 3 beta-28norursa-12,20(30)-dien-3-ol (2) and 3 beta-28-norursa-12,16,20(30)-triene-3-ol (3), as well as two known 3 beta-28norursa-17,19,21-trien-3-ol (4) and 3 beta-28-norursa-12-ene-3-ol (5) were isolated from the ethyl acetate dissolved fraction of the ethanol extract from Rosmarinus officinalis. Their structures were elucidated by HR-ESI-MS, IR, 1Dand 2D-NMR spectroscopic methods. Compounds 1-5 exhibited significant inhibitory effect on NO production in LPS-activated RAW264.7 cells, and compounds 2, 3 and 5 shown better anti-inflammatory activity.