登录    注册    忘记密码

详细信息

Cytotoxic monacolin analogs from Monascus purpureus-fermented rice  ( SCI-EXPANDED收录)  

文献类型:期刊文献

英文题名:Cytotoxic monacolin analogs from Monascus purpureus-fermented rice

作者:Liu, Ming-Tao[1,2];Wang, A-Li[1];Sun, Zhen[1];Li, Jin-Jie[1];Wu, Xiu-Li[3];Liu, Yan-Xia[1];Shang, Xiao-Ya[1]

第一作者:Liu, Ming-Tao

通讯作者:Shang, XY[1]

机构:[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]SRI Int, Menlo Pk, CA 94025 USA;[3]Ningxia Pharmaceut Univ, Coll Pharm, Yinchuan 750004, Peoples R China

第一机构:北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构:[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份:2013

卷号:15

期号:6

起止页码:600-609

外文期刊名:JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

收录:;WOS:【SCI-EXPANDED(收录号:WOS:000320691600002)】;

基金:We gratefully acknowledge financial support from the National Natural Science Foundation (Grant No. 31171669); the Beijing Natural Sciences Foundation (Grant No. 7102020); and Scientific Research Common Program of Beijing Municipal Commission of Education (Grant No. KM201111417001).

语种:英文

外文关键词:Monascus purpureus-fermented rice; monacolin analogs; absolute configuration; NMR; CD; cytotoxic activity

摘要:Two new monacolin analogs, monacolins O (1) and P (2), along with three known analogs, have been isolated from the ethanolic extract of Monascus purpureus-fermented rice. Their structures and absolute configurations were elucidated by spectroscopic methods, especially 2D NMR and CD spectral analyses as well as chemical method. Both 1 and 2 were tested against five tumor cell lines, and compound 1 exhibited selective cytotoxic activity against A2780 and A549 cell lines, with IC50 values of 3.7 and 8.0M, respectively.

参考文献:

正在载入数据...

版权所有©北京联合大学 重庆维普资讯有限公司 渝B2-20050021-8 
渝公网安备 50019002500408号 违法和不良信息举报中心