文献类型：期刊文献

英文题名：Cytotoxic monacolin analogs from Monascus purpureus-fermented rice

作者：Liu, Ming-Tao[1,2];Wang, A-Li[1];Sun, Zhen[1];Li, Jin-Jie[1];Wu, Xiu-Li[3];Liu, Yan-Xia[1];Shang, Xiao-Ya[1]

第一作者：Liu, Ming-Tao

通讯作者：Shang, XY[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]SRI Int, Menlo Pk, CA 94025 USA;[3]Ningxia Pharmaceut Univ, Coll Pharm, Yinchuan 750004, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2013

卷号：15

期号：6

起止页码：600-609

外文期刊名：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000320691600002)】；

基金：We gratefully acknowledge financial support from the National Natural Science Foundation (Grant No. 31171669); the Beijing Natural Sciences Foundation (Grant No. 7102020); and Scientific Research Common Program of Beijing Municipal Commission of Education (Grant No. KM201111417001).

语种：英文

外文关键词：Monascus purpureus-fermented rice; monacolin analogs; absolute configuration; NMR; CD; cytotoxic activity

摘要：Two new monacolin analogs, monacolins O (1) and P (2), along with three known analogs, have been isolated from the ethanolic extract of Monascus purpureus-fermented rice. Their structures and absolute configurations were elucidated by spectroscopic methods, especially 2D NMR and CD spectral analyses as well as chemical method. Both 1 and 2 were tested against five tumor cell lines, and compound 1 exhibited selective cytotoxic activity against A2780 and A549 cell lines, with IC50 values of 3.7 and 8.0M, respectively.