详细信息
Cytotoxic monacolin analogs from Monascus purpureus-fermented rice ( SCI-EXPANDED收录)
文献类型:期刊文献
英文题名:Cytotoxic monacolin analogs from Monascus purpureus-fermented rice
作者:Liu, Ming-Tao[1,2];Wang, A-Li[1];Sun, Zhen[1];Li, Jin-Jie[1];Wu, Xiu-Li[3];Liu, Yan-Xia[1];Shang, Xiao-Ya[1]
第一作者:Liu, Ming-Tao
通讯作者:Shang, XY[1]
机构:[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]SRI Int, Menlo Pk, CA 94025 USA;[3]Ningxia Pharmaceut Univ, Coll Pharm, Yinchuan 750004, Peoples R China
第一机构:北京联合大学应用文理学院|北京联合大学生物化学工程学院
通讯机构:[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;
年份:2013
卷号:15
期号:6
起止页码:600-609
外文期刊名:JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
收录:;WOS:【SCI-EXPANDED(收录号:WOS:000320691600002)】;
基金:We gratefully acknowledge financial support from the National Natural Science Foundation (Grant No. 31171669); the Beijing Natural Sciences Foundation (Grant No. 7102020); and Scientific Research Common Program of Beijing Municipal Commission of Education (Grant No. KM201111417001).
语种:英文
外文关键词:Monascus purpureus-fermented rice; monacolin analogs; absolute configuration; NMR; CD; cytotoxic activity
摘要:Two new monacolin analogs, monacolins O (1) and P (2), along with three known analogs, have been isolated from the ethanolic extract of Monascus purpureus-fermented rice. Their structures and absolute configurations were elucidated by spectroscopic methods, especially 2D NMR and CD spectral analyses as well as chemical method. Both 1 and 2 were tested against five tumor cell lines, and compound 1 exhibited selective cytotoxic activity against A2780 and A549 cell lines, with IC50 values of 3.7 and 8.0M, respectively.
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