文献类型：期刊文献

英文题名：The Optimization and Production of Ginkgolide B Lipid Microemulsion

作者：Wu, Xiao[1];Wang, Zhenpeng[2];Zhao, Zhenwen[2];Chen, Lei[1];Tao, Fengyun[1];Zhang, Qian[1];Zhou, Tuo[1];Cui, Junpu[1];Liu, Meng[1];Huo, Qing[1]

通讯作者：Huo, Q[1]

机构：[1]Beijing Union Univ, Biochem Engn Coll, Beijing 100023, Peoples R China;[2]Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China

第一机构：北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Biochem Engn Coll, Beijing 100023, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：2019

卷号：17

期号：1

起止页码：357-364

外文期刊名：OPEN CHEMISTRY

收录：;Scopus(收录号：2-s2.0-85068131119);WOS:【SCI-EXPANDED(收录号:WOS:000475786800001)】；

基金：This research was financially supported by the National Natural Science Foundation of China (Grants No. 11475020 and 8151114029) and Beijing Union University Graduate Program.

语种：英文

外文关键词：Ginkgolide B; Lipid microemulsion; Optimization

摘要：In this study, we introduce a method to formulate Ginkgolide B lipid microemulsion (GBLM). We have assessed its general characteristics and pharmacokinetics in animals. Soybean oil (10.0%) and oleic acid (2.4%) were chosen as the oil phase, refined egg yolk lecithin (PC98T) (1.8%) as the surfactant, and glycerol (2.25%) as the co-surfactant. The optimized formulation process resulted in particles with average diameter of 185.9 +/- 52.5 nm and the zeta potential of -19.8 +/- 1.3 mV. The GB-LM remained steady for three months at room temperature. Giving each dose of 4 mg/kg to rats through the vein, a clearance rate of CL (L/h): 2.594 and C max (ng/mL) was achieved: 353.8 through pharmacokinetic analysis and statistical analysis. The AUC of GB-LM was about 1.57-fold higher than that of the products available in the market. In addition, brain tissue distribution studies show that after 0.5 h administration of GB, the concentration of GB in brain tissue can reach its maximum, and then significantly decrease after 2 hours. Therefore, the improved formulation of GB-LM shows encouraging results compared with present products in several features.