文献类型：期刊文献

英文题名：Study of the self-assembly, drug encapsulating and delivering characteristics of short chain amylose-based type 3 resistant starch nanoparticles from Canna edulis

作者：Zhang, Chi[3]; Tang, Leimengyuan[1]; Wang, Nan[1]; Wu, Jiahui[1]; Zhang, Dachuan[1]; Li, Houxier[1]; Li, Yan[1]; Yang, Li[1]; Zhang, Nan[1]; Zhang, Yuan[2]; Wang, Xueyong[1]

第一作者：Zhang, Chi

机构：[1] School of Chinese Meteria Medica, Beijing University of Chinese Medicine, Northeast corner of the intersection of Sunshine South Street and Baiyang East Road, Fang-Shan District, Beijing, 102488, China; [2] College of Biochemical Engineering, Beijing Union University, No. 18, Fatou Xili District, Chaoyang District, Beijing, 100023, China; [3] School of Medicine, Linyi University, Shandong, Linyi, 276000, China

第一机构：School of Chinese Meteria Medica, Beijing University of Chinese Medicine, Northeast corner of the intersection of Sunshine South Street and Baiyang East Road, Fang-Shan District, Beijing, 102488, China

年份：2024

卷号：262

外文期刊名：International Journal of Biological Macromolecules

收录：EI(收录号：20240815596498);Scopus(收录号：2-s2.0-85185343577)

语种：英文

外文关键词：Controlled drug delivery - Cyclodextrins - Magnetite - Nanoparticles - Particle size - Recrystallization (metallurgy) - Starch - Synthesis (chemical) - Targeted drug delivery

摘要：In developing type 3 resistant starch (RS3) from Canna edulis for use as functional food ingredients, we investigated the synthesis of C. edulis RS3 nanoparticles. Simultaneously, we explored the potential of C. edulis short-chain amylose (SCA)-based RS3 nanoparticles (RS3N) as a targeted delivery system, with a specific focus on colon targeting, yielding promising insights. Our study revealed that the degree of polymerization (DP) of C. edulis SCA, particularly the chains of DP 36– 100, exhibited a robust correlation with the particle size and physicochemical characteristics of C. edulis SCA-based RS3N. Additionally, recrystallization temperature variation (4, 25, and 45 °C) significantly influenced the self-assembly behavior of C. edulis SCA, with the preparation at 4 °C resulting in more uniform particle size distributions. In further expanding the scope of applications for C. edulis SCA-based RS3N, we harnessed the potential of Fe3O4 and curcumin (CUR) as guest molecules to assess drug encapsulation and colon-targeting capabilities. Incorporating Fe3O4 into the self-assembly system led to the production of magnetic RS3N, confirming the successful encapsulation of Fe3O4 within C. edulis SCA-based RS3N. Furthermore, in vitro experiments have demonstrated that CUR-RS3N was stable in the gastrointestinal tract and gradually released curcumin with fermentation in the colonic environment. Collectively, these findings provide invaluable insights into the intricate self-assembly behavior of C. edulis SCA with varying fine structures and recrystallization temperatures during RS3N formation. Moreover, they underscore the colon-targeted properties of C. edulis SCA-based RS3N, opening promising avenues for its application within the food industry, particularly in advanced controlled drug delivery systems. ? 2024