文献类型：期刊文献

中文题名：Highland red rice-derived resistant starch and pigment extracts exert combined anti-hyperglycemic effects via the gut microbiota-PYY/GLP-1 pathway

作者：Leyi Zhao[1];Xinyu Shao[1];Liyuan Wang[1];Ziqing Cheng[1];Yawen Zeng[2];Shiquan Si[3];Xuhua Yang[3];Xia Li[2];Xiaomeng Yang[2];Lina Ye[1];Yuji Peng[1];Michael Zhang[4];Zuming Li[1]

第一作者：Leyi Zhao

机构：[1]College of Biochemical Engineering,Beijing Union University,Beijing,100023,China;[2]Biotechnology and Germplasm Resources Institute,Yunnan Academy of Agricultural Sciences,Kunming,650205,China;[3]Lijiang Ninglang Yikang Agricultural Products Development Co.,Ltd,Lijiang,674309,China;[4]Department of Physics and Astronomy,University of Manitoba,Winnipeg,MB,R3T 2N2,Canada

第一机构：北京联合大学生物化学工程学院

年份：2026

卷号：79

期号：5

起止页码：2364-2377

中文期刊名：Food Bioscience

外文期刊名：食品生物科学(英文)

基金：supported by the National Natural Science Foundation of China(No.31760376);National Key Assistance County Cluster Assistance Project of Lijiang Science and Technology Bureau(2022LJZTBF001);‘Qimingxing'Science and Technology Innovation Project Fund(20051055);Lijiang Ninglang Yikang Agricultural Products Development Co.,Ltd Cooperation Project(50304JA2337).

语种：英文

中文关键词：Highland red rice resistant starch;Antidiabetic;Gut microbiota-PYY/GLP-1 pathway

摘要：Highland red rice from southwestern China is recognized as a health-promoting grain,but its potential in dia-betes management remains underexplored.In this study,resistant starch(RS)and pigment extracts(RP)were isolated from highland red rice to determine whether they act in combination to modulate gut microbiota and metabolism in streptozotocin(STZ)-induced diabetic mice,with the aim of elucidating the mechanisms under-lying their anti-hyperglycemic effects.Neither RS nor RP single interventions significantly improved key gly-cemic parameters;however,the combined intervention(RSP)significantly reduced fasting blood glucose(FBG)levels and improved glucose tolerance.16S rRNA analysis indicated RSP intervention increased the abundance of short-chain fatty acid(SCFA)-producing bacteria,including Lactobacillus,Lactococcus,Akkermansia,and Rom-boutsia,while decreasing pro-inflammatory taxa such as Candidatus_Arthromitus.Metabolomic analysis revealed RSP intervention elevated levels of cholic acid(CA),hyocholic acid(HCA),and sphingolipid metabolism in-termediates(sphingosine and sphinganine).Crucially,both SCFA concentrations and the expression of peptide YY(PYY)and glucagon-like peptide-1(GLP-1)were significantly elevated after RSP intervention.These findings demonstrate that RS and RP together exert combined anti-hyperglycemic effects by modulating gut microbiota and its metabolites,thereby activating the PYY/GLP-1 signaling.This highlights the therapeutic potential of highland red rice components in diabetes management.