文献类型：期刊文献

英文题名：Four new monacolin analogs from Monascus purpureus-fermented rice

作者：Zhang, Bo[1];Liu, Tian-Xi[2];Wang, A-Li[1];Li, Jin-Jie[1];Wang, Xin[1];Luan, Na[1];Ji, Lin-Lin[1];Shang, Xiao-Ya[1]

第一作者：张斌;张波

通讯作者：Shang, XY[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]Lanzhou Univ, Dept Nephrol, Hosp 1, Lanzhou 730000, Gansu, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China.|[114172]北京联合大学应用文理学院;[11417]北京联合大学;[1141726]北京联合大学生物化学工程学院;

年份：2018

卷号：20

期号：3

起止页码：209-216

外文期刊名：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000427944800003)】；

基金：The work was financially supported by the National Natural Science Foundation of China [grant number 81773589]; Scientific Research Project from Facing Characteristic Discipline of Beijing Union University [grant number KYDE40201703]; and Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University [grant number LD-KZ-201601].

语种：英文

外文关键词：Monascus purpureus; monacolin analogs; isolation and elucidation

摘要：Four new monacolin analogs, monacolin T (1), monacolin U (2) 6a-O-methyl-4,6-dihydromonacolin L (3), and 6a-O-ethyl-4,6-dihydromonacolin L (4) were isolated from the ethanolic extract of Monascus purpureus-fermented rice. Their structures were determined by a combination of 1D, 2D NMR experiments (H-1-(HCOSY)-H-1, HSQC, HMBC, and ROESY), and mass spectrometry. In vitro cytotoxic assay, all compounds were inactive at the concentration of 10 mu M. [GRAPHICS] .