文献类型：期刊文献

英文题名：Mineralized collagen/Mg-Ca alloy combined scaffolds with improved biocompatibility for enhanced bone response following tooth extraction

作者：Yu, Qing[1];Wang, Chengyue[1];Yang, Jingxin[2];Guo, Changwu[1];Zhang, Shanning[1]

第一作者：Yu, Qing

通讯作者：Wang, CY[1];Yang, JX[2]

机构：[1]Jinzhou Med Univ, Dept Prosthodont, Affiliated Hosp 2, Jinzhou, Peoples R China;[2]Beijing Union Univ, Coll Robot, Beijing, Peoples R China

第一机构：Jinzhou Med Univ, Dept Prosthodont, Affiliated Hosp 2, Jinzhou, Peoples R China

通讯机构：[1]corresponding author), Jinzhou Med Univ, Dept Prosthodont, Affiliated Hosp 2, Jinzhou, Peoples R China;[2]corresponding author), Beijing Union Univ, Coll Robot, Beijing, Peoples R China.|[1141739]北京联合大学机器人学院;[11417]北京联合大学;

年份：2018

卷号：13

期号：6

外文期刊名：BIOMEDICAL MATERIALS

收录：;EI(收录号：20184406008076);Scopus(收录号：2-s2.0-85055531179);WOS:【SCI-EXPANDED(收录号:WOS:000443267000002)】；

基金：This research was supported by Science and Technology Fund of Liaoning Province (No. 2015020689), Premium Funding project for Academic Human Resources Development in Beijing Union University and Improve the Level of Scientific Research: Quota-Oriented Features of Discipline Research Project by Beijing Union University (Grant No. KYDE40201708).

语种：英文

外文关键词：mineralized collagen; Mg-Ca alloy; biocompatibility; bone regeneration

摘要：Mineralized collagen has been used clinically as a bone grafting material in oral applications. We have developed a mineralized collagen/Mg-Ca alloy combined scaffold to overcome the mechanical limitations of mineralized collagen. This study discusses the cytocompatibility of the mineralized collage/Mg-Ca alloy combined scaffold in vitro and the bone regeneration following tooth extraction in vivo. Using an indirect proliferation assay adapted from ISO 10993-5, it was found that mineralized collagen/Mg-Ca alloy combined scaffold enhanced cell proliferation and migration in addition to MC3T3-E1 cells not showing a cytotoxicity response in vitro. Finally, the ability of the combined scaffold to enhance osteogenesis was assessed in a canine socket preservation model. Cone beam CT, x-ray microscopes and biomechanical analysis showed the mineralized collagen/Mg-Ca alloy combined scaffold to be more effective at reducing the absorption of alveolar ridge and preserving the socket site than mineralized collagen alone. The combined scaffolds can promote bone regeneration with good biocompatibility, providing a new concept of the combined application of mineralized collagen and magnesium alloy.