文献类型：期刊文献

英文题名：Qingke β-glucan and Lactobacillus mitigate neuroinflammation and enhance cognitive function in an Alzheimer's disease mouse model

作者：Wu, Yusong[1,2]; Shao, Yong[3]; Shao, Xinyu[2]; Yu, Hailong[4]; Wang, Miao[1]; Wang, Jing[1]; She, Yongxin[1]; Liu, Jia[5]; Zhang, Tangwei[6]; Li, Zuming[2]; Abd El-Aty, A.M.[7,8]

第一作者：Wu, Yusong

机构：[1] State Key Laboratory for Quality and Safety of Agro-Products, Institute of Quality Standardization & Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing, 100081, China; [2] College of Health and Environment, Beijing Union University, Beijing, 100081, China; [3] Key Laboratory of Geriatric Nutrition and Health, Ministry of Education, Beijing Technology and Business University, Beijing, 100048, China; [4] Institute of Health Research of COFCO Corporation, Beijing, 102209, China; [5] College of Bioengineering, Beijing Polytechnic, Beijing, 100176, China; [6] Institute of Agricultural Product Quality Standard and Testing Research, Xizang Academy of Agricultural and Animal Husbandry Sciences, Xizang, Lhasa, 850032, China; [7] Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt; [8] Department of Medical Pharmacology, Medical Faculty, Ataturk University, Erzurum, 25240, Turkey

第一机构：State Key Laboratory for Quality and Safety of Agro-Products, Institute of Quality Standardization & Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing, 100081, China

年份：2025

卷号：319

外文期刊名：International Journal of Biological Macromolecules

收录：EI(收录号：20252618686693);Scopus(收录号：2-s2.0-105009129314)

语种：英文

外文关键词：Brain - Mammals - Metabolism - Neurons

摘要：Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders and substantially impacts cognitive health and quality of life. Qingke β-glucan (Q) and its combination with Lactobacillus (Q&P) demonstrated a notable ability to alleviate anxiety behaviors and improve cognitive and learning memory deficits in APP/PS1 mice, a widely used model for AD. Q&P effectively reduced amyloid-β accumulation and Tau phosphorylation, protecting neurons from degeneration. Additionally, it increased the mRNA expression of BDNF and SYP, reduced synaptic damage, and suppressed neuroinflammation by decreasing the mRNA levels of IL-6, IL-17 A, and IL-22. Q&P also activated the Nrf2 signaling pathway, enhanced SOD activity, mitigated oxidative damage, and restored gut microbiota dysbiosis. Metabolomic and 16S rRNA sequencing analyses revealed significant modulation of the intestinal microbiome and metabolic pathways, with key roles identified for Lactobacillus, Muribaculum, Candidatus_Stoquefichus, and Coriobacteriaceae_UCG-002. These microbiota adjustments influence tryptophan and linoleic acid metabolism, contributing to reduced inflammation and oxidative stress and improving neuronal health. By enhancing the intestinal microenvironment and regulating metabolic and microbial profiles, Q&P offers a sustainable and effective approach for preventing cognitive decline and promoting overall brain health in AD patients. ? 2025 Elsevier B.V.