文献类型：期刊文献

英文题名：Recent advances in DHA-containing phospholipids (PL-DHA): Sources, position-specific effects, metabolic pathways, and biological activities

作者：He, Yi[1];Liu, Bo[1];Ma, Xuan[1];Hu, Xiuyu[2];Yan, Wenjie[1,3];Wang, Feng[1]

通讯作者：Wang, F[1]

机构：[1]Beijing Union Univ, Coll Biochem Engn, Beijing, Peoples R China;[2]China Biotech Fermentat Ind Assoc, Beijing, Peoples R China;[3]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Food, Beijing, Peoples R China

第一机构：北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Coll Biochem Engn, Beijing, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：2025

卷号：218

外文期刊名：FOOD RESEARCH INTERNATIONAL

收录：;EI(收录号：20252518639341);Scopus(收录号：2-s2.0-105008375260);WOS:【SCI-EXPANDED(收录号:WOS:001517356300006)】；

基金：Funding This research was funded by National Key Research and Develop-ment Program (2023YFF1103804) , Major Science and Technology Project of Henan Province (No.231100310200) , and the Academic Research Projects of Beijing Union University (No. ZK10202306) .

语种：英文

外文关键词：PL-DHA; Position-specific effects; Metabolic pathways; Biological activity; Structure-function relationships; Membrane organization

摘要：Docosahexaenoic acid-containing phospholipid (PL-DHA) exhibits superior bioavailability compared to conventional DHA formulations. Derived primarily from Antarctic krill or enzymatic synthesis, PL-DHA's molecular architecture-specifically its position-dependent distribution within the glycerol backbone and polar headgroup variations-critically influences membrane dynamics. Sn-1 position DHA generates "U-shaped" configurations affecting membrane fluidity, while sn-2 position maintains "hairpin" conformations optimal for enzymatic recognition. These structural characteristics enable specialized transport mechanisms, including Mfsd2amediated blood-brain barrier penetration. PL-DHA undergoes distinct tissue-specific metabolism, particularly in neural and hepatic tissues, modulating membrane properties and signal transduction. Its biological activities encompass anti-inflammatory, neuroprotective, and metabolic regulatory functions through both direct membrane effects and bioactive metabolite generation. This structure-function relationship provides crucial insights for developing targeted therapeutic applications in neurological and metabolic disorders.