文献类型：期刊文献

英文题名：The mood stabilizer lamotrigine produces antidepressant behavioral effects in rats: role of brain-derived neurotrophic factor

作者：Li, Nanxin[1,2,3];He, Xiaolu[3];Qi, Xiaoli[4];Zhang, Yu[5];He, Shuchang[3]

第一作者：Li, Nanxin

通讯作者：Li, NX[1]

机构：[1]Yale Univ, Div Mol Psychiat, Sch Med, New Haven, CT 06508 USA;[2]Yale Univ, Dept Psychol, New Haven, CT 06520 USA;[3]Peking Univ, Dept Psychol, Beijing 100871, Peoples R China;[4]Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China;[5]Beijing Union Univ, Dept Biol, Coll Arts & Sci, Beijing 100083, Peoples R China

第一机构：Yale Univ, Div Mol Psychiat, Sch Med, New Haven, CT 06508 USA

通讯机构：[1]corresponding author), Yale Univ, Div Mol Psychiat, Sch Med, 34 Pk St, New Haven, CT 06508 USA.

年份：2010

卷号：24

期号：12

起止页码：1772-1778

外文期刊名：JOURNAL OF PSYCHOPHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-77955069785);WOS:【SCI-EXPANDED(收录号:WOS:000285044500006)】；

基金：This project was funded by Natural Science Foundation of China (Grant No. 30870768).

语种：英文

外文关键词：antidepressant; brain derived neurotrophic factor; forced swimming test; lamotrigine; learned helplessness

摘要：The anticonvulsant drug lamotrigine has been shown to produce strong antidepressant effects in the treatment of patients with bipolar disorder. However, to date there are few preclinical reports on its behavioral actions in animal models of depression or its underlying molecular mechanisms. The current study investigated the effects of lamotrigine in the forced swimming test and the learned helplessness test. The results demonstrate that both 15 and 30 mg/kg acute treatment of lamotrigine significantly reduced immobility in the forced swimming test without affecting locomotor activity. Sub-chronic twice daily injections of 30 mg/kg lamotrigine robustly decreased escape failures in animals that had developed learned helplessness symptoms. In parallel, the sub-chronic lamotrigine treatment also up-regulated frontal and hippocampal brain-derived neurotrophic factor expression in both naive and stressed animals and restored the stress-induced down-regulation of brain-derived neurotrophic factor expression. This study provides further evidence for the use of lamotrigine as a novel antidepressant in the treatment of bipolar disorders.