文献类型：期刊文献

中文题名：铁皮石斛对运动训练大鼠物质代谢及抗运动疲劳能力的影响

英文题名：Effect of Dendrobium officinale Kimura et Migo on Substance Metabolism and Exercise Capacity in Rats After Exercise Training

作者：周海涛[1];曹建民[2];林强[3];赵卓[3]

第一作者：周海涛

机构：[1]北京联合大学生物化学工程学院;[2]北京体育大学;[3]北京联合大学应用文理学院

第一机构：北京联合大学生物化学工程学院

年份：2013

卷号：48

期号：19

起止页码：1684-1688

中文期刊名：中国药学杂志

外文期刊名：Chinese Pharmaceutical Journal

收录：CSTPCD;;Scopus;北大核心:【北大核心2011】；CSCD:【CSCD2013_2014】；PubMed;

基金：北京市属高等学校人才强教计划资助项目(PHR201107150)

语种：中文

中文关键词：铁皮石斛;物质代谢;抗疲劳;大鼠;肝糖原;肌糖原;血尿素;血红蛋白

外文关键词：Dendrobium officinale Kimura et Migo; substance metabolism; anti-fatigue; rat; liver glycogen; muscle glycogen;blood urea nitrogen; hemoglobin

摘要：目的研究铁皮石斛对运动训练大鼠物质代谢及抗运动疲劳能力的影响。方法以大强度耐力训练大鼠为模型,55只42 d龄雄性Wistar大鼠为对象,随机分为5组:静止对照组(C组)、运动对照组(T组)、运动ig低剂量铁皮石斛组(TML组),运动ig中剂量铁皮石斛组(TMM组),运动ig高剂量铁皮石斛组(TMH组),每组10只(剔除不符合实验要求的大鼠)。采用专业灌胃器每天ig一次,低、中、高剂量组ig剂量分别为1.5、3、4.5 g·kg-1·d-1,ig体积为5 mL·kg-1,C、T组ig等量生理盐水。末次训练24 h后,测定体重、力竭游泳时间及血红蛋白等生化指标。结果 TM各组间体重无显著差异,且大于T组(P<0.05),小于C组(P<0.05);TM各组力竭游泳时间长于C、T组(P<0.01),且随剂量增大而延长;长时间力竭运动导致肝糖原、肌糖原储量下降[T组(P<0.01)、TM各组(P<0.05)低于C组;TM各组肝糖原(P<0.05)、肌糖原(P<0.01)高于T组,组间无显著差异,且随剂量增大而增高];血尿素氮上升[T组(P<0.01),TM各组(P<0.05)高于C组;TM各组低于T组(P<0.05),且组间无显著差异];血红蛋白下降[T组(P<0.01),TM各组(P<0.05)低于C组;TM各组高于T组(P<0.05),组间无显著差异]。结论补充铁皮石斛可以促进蛋白质合成,抑制氨基酸和蛋白质分解,提高血红蛋白含量和糖原的储备,增强抗疲劳能力,具有多靶点、多途径的显著特点。
OBJECTIVE To study the effects of Dendrobium officinale Kimura et Migo on the rats substance metabolism and anti- exercise fatigue capacity in the exercise training. METHODS High-intensity endurance training rat was as a model. Divided the 6- week-old male（42 d age）Wistar rats 55 into 5 groups of 10 （removed the rats, which are not meeting the requirement） ： still group （group C） , exercise group（ group T）, exercise ig low-dose Dendrobium officinale Kimura et Migo group of（ group TML）, exercise ig middle-dose of Dendrobium officinale Kimnra et Migo group （ group TMM ）, exercise ig high-dose of Dendrobium officinale Kimura et Migo group （ group TMH）. Garage using professional device ig once a day, group TML, Group TMM, group TMH ig dose was 1.5,3, 4. 5 g ~ kg- ~ ~ d - ~ , the ig volume 5 mL ~ kg - ~, Group C and group T were added to ig the same amount of saline. For 24 h after the last training, measured weight, exhaustive swimming time, Hemoglobin and other biochemical mm＇kers. RESULTS The TM each weight no significant differences, and greater than the group T（P 〈0. 05） less than group C（P 〈0. 05）. TM swimming time is longer than the group C and group T（P 〈0.01 ） , and the dose increased and extended. Prolonged exhaustive exercise lead to liver glycogen, muscle glycogen reserves decreased（group T（P 〈0. 01 ）, groups TM（P 〈0. 05） lower than in group C. TM each group of liver glyco- gen[P 〈0. 05）, inositol the original（P 〈 0. 01 ] higher than the group T, no significant differences between each group of the TM, with the dose increase and higher）. In addition, blood urea nitrogen rise ~ group T（ P 〈 0. 01 ） and groups TM （ P 〈 0.05 ） blood urea ni- trogen higher than in group C. Groups TM is lower than the group T（P 〈 0. 05 ） , TM each non-significant difference]. Hemoglobin de- creased [ group T（ P 〈 0. 01 ）, groups TM （ P 〈 0. 05 ） lower than in group C. Groups TM is higher than the group T （ P 〈 0. 05 ） , no significant difference between the TM each 1. CONCLUSION Dendrobium officinale Kimura et Migo supplement can promote protein synthesis, inhibition of amino acid and protein degradation, thereby increasing the hemoglobin content and glycogen reserves, enhanced resistance to fatigue, it has a muhi-target, multi-channel features.