文献类型：期刊文献

英文题名：The synergism of Lactobacillaceae, inulin, polyglucose, and aerobic exercise ameliorates hyperglycemia by modulating the gut microbiota community and the metabolic profiles in db/db mice

作者：Li, Peifan[1]; Tong, Tong[1]; Shao, Xinyu[1]; Han, Yan[1]; Zhang, Michael[2,3]; Li, Yongli[4]; Lv, Xue[4]; Li, Hao[5]; Li, Zuming[1]

第一作者：Li, Peifan

机构：[1] College of Biochemical Engineering, Beijing Union University, Beijing, 100023, China; [2] Department of Physics and Astronomy, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada; [3] Sino Canada Health Engineering Research Institute, Hefei, China; [4] Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, 450003, China; [5] Fuwai Central China Cardiovascular Hospital, Zhengzhou, 450003, China

第一机构：北京联合大学生物化学工程学院

通讯机构：[5]Fuwai Central China Cardiovascular Hospital, Zhengzhou, 450003, China;[1]College of Biochemical Engineering, Beijing Union University, Beijing, 100023, China|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：2024

卷号：15

期号：9

起止页码：4832-4851

外文期刊名：Food and Function

收录：EI(收录号：20241715949344);Scopus(收录号：2-s2.0-85190748176)

语种：英文

外文关键词：Bacteria - Fatty acids - Mammals - Metabolism

摘要：This study aimed to assess the impact of Lactobacillaceae (L or H represents a low or high dose), inulin (I), and polydextrose (P) combined with aerobic exercise (A) on the composition of the gut microbiota and metabolic profiles in db/db mice. After a 12-week intervention, LIP, LIPA, and HIPA groups exhibited significant improvements in hyperglycemia, glucose tolerance, insulin resistance, inflammatory response, and short-chain fatty acid (SCFA) and blood lipid levels compared to type 2 diabetes mice (MC). After treatment, the gut microbiota composition shifted favorably in the treatment groups which significantly increased the abundance of beneficial bacteria, such as Bacteroides, Blautia, Akkermansia, and Faecalibaculum, and significantly decreased the abundance of Proteus. Metabolomics analysis showed that compared to the MC group, the contents of 5-hydroxyindoleacetic acid, 3-hydroxysebacic acid, adenosine monophosphate (AMP), xanthine and hypoxanthine were significantly decreased, while 3-ketosphinganine, sphinganine, and sphingosine were significantly increased in the LIP and LIPA groups, respectively. Additionally, LIP and LIPA not only improved sphingolipid metabolism and purine metabolism pathways but also activated AMP-activated protein kinase to promote β-oxidation by increasing the levels of SCFAs. Faecalibaculum, Blautia, Bacteroides, and Akkermansia exhibited positive correlations with sphingosine, 3-ketosphinganine, and sphinganine, and exhibited negative correlations with hypoxanthine, xanthine and AMP. Faecalibaculum, Blautia, Bacteroides, and Akkermansia may have the potential to improve sphingolipid metabolism and purine metabolism pathways. These findings suggest that the synergism of Lactobacillaceae, inulin, polydextrose, and aerobic exercise provides a promising strategy for the prevention and management of type 2 diabetes. ? 2024 The Royal Society of Chemistry.