文献类型：期刊文献

英文题名：Fermented soy whey induced changes on intestinal microbiota and metabolic in?uence in mice

作者：Han, Wei[1];Zhuang, Xuhui[1];Liu, Qian[2];Sun, Bo[1];Miao, Haijiang[1];Zhang, Xiaolin[3]

第一作者：Han, Wei

通讯作者：Han, W[1];Zhang, XL[2]

机构：[1]Acad State Adm Grain, Beijing 100037, Peoples R China;[2]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[3]COFCO Nutr & Hlth Inst, Beijing 102209, Peoples R China

第一机构：Acad State Adm Grain, Beijing 100037, Peoples R China

通讯机构：[1]corresponding author), Acad State Adm Grain, Beijing 100037, Peoples R China;[2]corresponding author), COFCO Nutr & Hlth Inst, Beijing 102209, Peoples R China.

年份：2022

卷号：11

期号：1

起止页码：41-48

外文期刊名：FOOD SCIENCE AND HUMAN WELLNESS

收录：;Scopus(收录号：2-s2.0-85122539399);WOS:【SCI-EXPANDED(收录号:WOS:000695531000005)】；

语种：英文

外文关键词：Soy whey; Microbiota; Short chain fatty acids; Lactobacillus casei; Akkermansia muciniphila

摘要：Soy whey (SW) is generated as process waste while preparing soy protein isolates (SPI), and causing severe environmental pollution. Therefore, its value-added utilization is of prime importance for transforming and upgrading traditional industry. This study aims to utilize SW as a substrate for the growth of probiotics and produce a SW based synbiotics. By a series of trials, the effect of the dietary supplementation with this fermented SW (FSW) was analyzed on ICR mice's body weight, metabolites, and intestinal microbiota in 4 weeks. The results showed that, when SW was concentrated 15 times, the count of viable Lactobacillus casei reached 3.4 x 10(9) CFU/mL by liquid fermentation method, which was the highest viable cell count among all test strains. In this FSW, the protein, amino acid, total dietary fibre, soluble dietary fibre, and oligosaccharide were 2.10%, 1.63%, 0.52%, 0.51% and 0.79%, respectively. Compared to two control group, the total yields of the short chain fatty acids (SCFAs) were significantly improved (75%125% at average), while the SCFAs structure was also significantly changed (especially acetic acid and butyrate) in the faeces of mice fed FSW. Meanwhile, FSW dietary addition was associated with the diversity and richness of the intestinal microbiota. Obviously, with mice's body weight loss, Firmicutes/Bacteroides ratio reduced accordingly (< 1.21), and the abundance of Akkermansia muciniphila was significantly increased (the maximum amount was about 0.013%). In summary, our results indicated that the dietary supplementation of FSW affected mice's intestinal microbiota and metabolism and improved their health profile. (C) 2021 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co, Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).