文献类型：期刊文献

英文题名：Bioassay-Guided Isolation of Triterpenoids as -Glucosidase Inhibitors from Cirsium setosum

作者：Li, Xiuting[1];Zhong, Xiangjian[2];Wang, Xin[2];Li, Jinjie[2];Liu, Jiachen[2];Wang, Kaiqi[2];Yue, Jianyu[2];Yang, Ximiao[2];Shang, Xiaoya[2];Lin, Sheng[3,4]

第一作者：Li, Xiuting

通讯作者：Shang, XY[1];Lin, S[2];Lin, S[3]

机构：[1]Beijing Technol & Business Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100048, Peoples R China;[2]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100023, Peoples R China;[3]Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China;[4]Peking Union Med Coll, Beijing 100050, Peoples R China

第一机构：Beijing Technol & Business Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100048, Peoples R China

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100023, Peoples R China;[2]corresponding author), Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China;[3]corresponding author), Peking Union Med Coll, Beijing 100050, Peoples R China.|[114172]北京联合大学应用文理学院;[11417]北京联合大学;[1141726]北京联合大学生物化学工程学院;

年份：2019

卷号：24

期号：10

外文期刊名：MOLECULES

收录：;Scopus(收录号：2-s2.0-85066071292);WOS:【SCI-EXPANDED(收录号:WOS:000470996600002)】；

基金：The work was supported by the Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University (Grant No. 20171040); the Key projects of the Beijing Natural Sciences Foundation and Beijing Municipal Education Committee (No. KZ201811417049); and the Strengthening University by Talents Program of Beijing Union University (Grant No. BPHR2018AZ01).

语种：英文

外文关键词：Cirsium setosum; -glucosidase inhibitor; isolation and purification; triterpenoid

摘要：Cirsium setosum (C. setosum) has a potential antihyperglycemic effect, but it is unclear what bioactive components play a key role. According to the -glucosidase inhibition activity, three new taraxastane-type triterpenoids of 3-hydroxy-30-hydroperoxy-20-taraxastene (1), 3-hydroxy-22-methoxy-20-taraxastene (2), and 30-nor-3,22-dihydroxy-20-taraxastene (3), as well as five known taraxastane triterpenoids of 3,22-dihydroxy-20-taraxastene (4), 20-taraxastene-3,22-dione (5), 3-acetoxy-20-taraxasten-22-one (6), 3-hydroxy-20-taraxasten-22-one (7), and 30-nor-3-hydroxy-20-taraxastene (8) were obtained from the petroleum ether-soluble portion of the ethanol extract from C. setosum. All chemical structures of the compounds were elucidated by spectroscopic data analysis and compared with literature data. Compounds 4-8 were identified for the first time from this plant, and compounds 1, 2, 4, and 7 exhibited more potent -glucosidase inhibitory activitywith IC50 values of 18.34 +/- 1.27, 26.98 +/- 0.89, 17.49 +/- 1.42, and 22.67 +/- 0.25 M, respectivelythan acarbose did (positive control, IC50 42.52 +/- 0.32 M).