文献类型：期刊文献

英文题名：Potential Protective Effect of Selenium-Enriched Lactobacillus plantarum on Cadmium-Induced Liver Injury in Mice

作者：Song, Yanyan[1];Zhang, Jing[1];Li, Yidan[1];Wang, Yuxuan[1];Wan, Yingxin[1]

第一作者：Song, Yanyan

通讯作者：Wan, YX[1]

机构：[1]Beijing Union Univ, Coll Biochem Engn, Beijing 100023, Peoples R China

第一机构：北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Coll Biochem Engn, Beijing 100023, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：2024

卷号：34

期号：6

起止页码：1328-1339

外文期刊名：JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

收录：;Scopus(收录号：2-s2.0-85197341884);WOS:【SCI-EXPANDED(收录号:WOS:001259891600017)】；

基金：This work was supported by the Science and Technology Project of Beijing Union University (ZK30202302) and the Education and Teaching Research and Reform Project of Beijing Union University (JJ2022Y020) .

语种：英文

外文关键词：Selenium -enriched Lactobacillus plantarum; selenium nanoparticles; liver; Cd

摘要：Cadmium (Cd) is a prevalent environmental contaminant that poses a potential hazard to the health of both humans and animals. In this study, biosynthesized selenium-enriched Lactobacillus plantarum and selenium nanoparticles (SeNPs) were developed and evaluated for their protective effects against Cd-induced hepatic injury in mice through oral administration for 4 weeks. Cadmium exposure resulted in severe impairment of liver function, as evidenced by increased levels of serum markers of liver injury and, oxidative stress and significant damage to liver tissue, and a notable decrease in the diversity of the intestinal microbiota. Oral administration of Se-enriched L. plantarum (LS) reduced cadmium accumulation in the liver by 49.5% and, restored other cadmium-induced damage markers to normal levels. A comparison of the effects with those of L. plantarum (L) and SeNPs isolated from LS revealed that LS could more effectively alleviate hepatic oxidative stress and reduce the intrahepatic inflammatory responses of the liver, further protecting against cadmiuminduced liver injury. These findings suggest that the development of LS may be effective at protecting the liver and intestinal tract from cadmium-induced damage.