文献类型：期刊文献

英文题名：Sirolimus-loaded CaP coating on Co-Cr alloy for drug-eluting stent

作者：Yang, Jingxin[1,2];Lee, In-Seop[3];Cui, Fuzhai[4]

第一作者：杨静馨;Yang, Jingxin

通讯作者：Yang, JX[1]

机构：[1]Beijing Union Univ, Coll Mech & Elect Engn, Mat Sci & Engn, Beijing 100020, Peoples R China;[2]Beijing Engn Res Ctr, Smart Mech Innovat Design Serv, Beijing 100020, Peoples R China;[3]Yonsei Univ, Atom Scale Surface Sci Res Ctr, Seoul 120749, South Korea;[4]Tsinghua Univ, Sch Mat Sci & Engn, Beijing 100084, Peoples R China

第一机构：北京联合大学机器人学院

通讯机构：[1]corresponding author), 4 North Rd Workers Stadium, Beijing 100020, Peoples R China.

年份：2016

卷号：3

期号：3

起止页码：167-171

外文期刊名：REGENERATIVE BIOMATERIALS

收录：;EI(收录号：20193207286463);Scopus(收录号：2-s2.0-85006783657);WOS:【SCI-EXPANDED(收录号:WOS:000387387300003)】；

语种：英文

外文关键词：drug-eluting system; Co-Cr alloy; sirolimus

摘要：To achieve polymer-free and controllable drug-eluting system, there have been many efforts to modify the surface composition and topography of metal stent. Recently, calcium phosphate is commonly applied to metallic implants as a coating material for fast fixation and firm-implant bone attachment on the account of its demonstrated bioactive and osteoconductive properties. In the present study, the release of sirolimus could be controllable because of immobilization of sirolimus during the process of biomimetic CaP coating forming. A completely new concept is the drug carrier of biomimetic CaP coating with sirolimus for an absorbable drug eluting system, which in turn can serve as a drug reservoir. We here describe the characteristic, mechanisms and drug release in vitro of new drug-eluting system in comparison to conventional system equivalent. Nano-structured calcium phosphate (CaP) coating was formed on the cobalt-chromium (Co-Cr) alloy substrate. By immersing coated sample in solution with sirolimus (rapamycin), the sirolimus could be immobilized in the newly formed CaP layer. The morphology, composition and formation process of the coating were studied with scanning electron microscopy, energy dispersive spectrometer, X-ray diffraction and X-ray photoelectron spectroscopy. The results showed that a uniform CaP coating incorporated with sirolimus was observed on Co-Cr alloy.