文献类型：期刊文献

英文题名：Plasma glucose and hemoglobin A1c for the detection of diabetes in Chinese adults

作者：Xu, Yu[1,2];Zhao, Wenhua[3];Wang, Weiqing[1,2];Bi, Yufang[1,2];Li, Jianhong[4];Mi, Shengquan[3,5];Xu, Min[1,2];Lu, Jieli[1,2];Wang, Tiange[1,2];Li, Mian[1,2];Wang, Zhuoqun[4];Jiang, Yong[4];Wang, Limin[4];Wang, Linhong[4];Dai, Meng[1,2];Zhang, Di[1,2];Lai, Shenghan[6];Ning, Guang[1,2]

第一作者：Xu, Yu

通讯作者：Ning, G[1]

机构：[1]Shanghai Jiao Tong Univ, State Key Lab Med Genom, Key Lab Endocrine & Metab Dis,Sch Med, Minist Hlth,Natl Clin Res Ctr Metab Dis,Rui Jin H, Shanghai 200030, Peoples R China;[2]Shanghai Jiao Tong Univ, Shanghai Clin Ctr Endocrine & Metab Dis, Rui Jin Hosp, Sch Med, Shanghai 200030, Peoples R China;[3]Beijing Union Univ, Coll Appl Art & Sci, Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China;[4]Beijing Union Univ, Coll Appl Art & Sci, Natl Ctr Chron & Noncommunicable Dis Control & Pr, Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China;[5]Beijing Union Univ, Dept Food Sci, Coll Appl Art & Sci, Beijing, Peoples R China;[6]Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

第一机构：Shanghai Jiao Tong Univ, State Key Lab Med Genom, Key Lab Endocrine & Metab Dis,Sch Med, Minist Hlth,Natl Clin Res Ctr Metab Dis,Rui Jin H, Shanghai 200030, Peoples R China

通讯机构：[1]corresponding author), Shanghai Jiao Tong Univ, Dept Endocrine & Metab Dis, Rui Jin Hosp, Key Lab Endocrine & Metab Dis,Minist Hlth,Sch Med, 197 Rui Jin 2nd Rd, Shanghai 200025, Peoples R China.

年份：2016

卷号：8

期号：3

起止页码：378-386

外文期刊名：JOURNAL OF DIABETES

收录：;Scopus(收录号：2-s2.0-84964056053);WOS:【SCI-EXPANDED(收录号:WOS:000373948100010)】；

基金：This work was supported by the Chinese Ministry of Finance (1994DP131044 from the Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, 2013BAI09B13 from the China National Clinical Research Center for Metabolic Diseases of Ministry of Health, 2012ZX09303006-001 from the National Key New Drug Creation and Manufacturing Program of Ministry of Science and Technology, 2012AA02A509 from the National High Technology Research and Development Program of China [ 863 Program], 81321001, 81390350, 81222008, 81130016, 81100564 from the National Natural Science Foundation of China, and 13495810200 from the Shanghai Municipal of Science and Technology). The authors thank the investigating staff and study participants for their important contributions.

语种：英文

外文关键词：diabetes; HbA1c; plasma glucose

摘要：BackgroundThe aim of the present study was to evaluate the performance of plasma glucose (PG) and HbA1c for the detection of diabetes in the general population in China. MethodsA cross-sectional analysis was conducted in a nationally representative sample of 98658 Chinese adults aged 18 years. Fasting plasma glucose and HbA1c levels were measured in all participants after at least a 10-h overnight fast. An oral glucose tolerance test (OGTT) was conducted among participants without a self-reported history of diagnosed diabetes. ResultsAn HbA1c 6.5% could identify 4.57% of Chinese adults as having newly detected diabetes, followed by fasting PG (FPG) and 2-h PG at 4.52% and 3.50%, respectively. Approximately 1.95% of the total population was detected by HbA1c but not by FPG or 2-h PG. However, FPG plus HbA1c could identify most (85.2%) diabetic individuals identified by any of the three tests (i.e. FPG, 2-h PG, and HbA1c). Levels of most cardiovascular risk factors, such as body mass index, waist circumference, and cholesterol, were higher in diabetes detected by HbA1c alone than in diabetes identified by the OGTT. ConclusionsAlthough HbA1c 6.5% has been recommended by the American Diabetes Association as one of the diagnostic tests for diabetes, caution should be used to avoid potential overdiagnosis when interpreting diabetes identified by elevated HbA1c alone.