文献类型：期刊文献

英文题名：A Three-Component Approach to (Hetero)arenes with Two N -Containing Heterocycle Motifs

作者：Zhang, Yuliang[1]; Zhang, Yang[1]; Qiu, Hong[1]; Wang, Liqin[1]; Ge, Xizhen[3]; Wang, Zhen[2]; Yu, Xinhong[1]

第一作者：Zhang, Yuliang

机构：[1] East China University of Science, Technology Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, Shanghai Key Laboratory of New Drug Design, Shanghai, 200237, China; [2] College of Pharmacy, Linyi University, Linyi, 276000, China; [3] College of Biochemical Engineering, Beijing Union University, Beijing, 100023, China

第一机构：East China University of Science, Technology Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, Shanghai Key Laboratory of New Drug Design, Shanghai, 200237, China

年份：2022

卷号：54

期号：24

起止页码：5445-5450

外文期刊名：Synthesis (Germany)

收录：EI(收录号：20223412600266);Scopus(收录号：2-s2.0-85136059925)

语种：英文

外文关键词：Isomerization - Isomers

摘要：A one-pot, three-component reaction involving SNAr-decarboxylative redox isomerization starting from an electron-withdrawing group bearing fluorobenzaldehyde or fluorothiophenecarbaldehyde (electron-pair diacceptor), secondary amine, and trans-4-hydroxy-Lproline or indoline-2-carboxylic acid (electron-pair donor) has been developed to give N-[(pyrrolylmethyl)-substituted (het)aryl]- and N-[(indolylmethyl)-substituted (het)aryl]pyrrolidines, -piperidines, -morpholines, and -azocanes. The highlights of this protocol are its great convenience in the simultaneous construction of a C(sp2)?N bond and a C(sp3)?N bond with simple operation; the reaction can be performed on a gram scale. This efficient one-pot multicomponent reaction has potential as a novel method for drug synthesis, especially involving polycyclic compounds. ? 2022 Georg Thieme Verlag. All rights reserved.