文献类型：期刊文献

英文题名：Triterpenoids from the roots of Pterospermum heterophyllum Hance

作者：Li, Shuai[1];Shi, Yan[1];Shang, Xiao-Ya[2];Cui, Bao-Song[1];Yuan, Yi[1];Chen, Xiao-Guang[1];Yang, Yong-Chun[1];Shi, Jian-Gong[1]

第一作者：Li, Shuai

通讯作者：Li, S[1]

机构：[1]Chinese Acad Med Sci, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Inst Mat Med, Beijing 100050, Peoples R China;[2]Beijing Union Univ, Coll Arts & Sci, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100083, Peoples R China

第一机构：Chinese Acad Med Sci, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Inst Mat Med, Beijing 100050, Peoples R China

通讯机构：[1]corresponding author), Chinese Acad Med Sci, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Inst Mat Med, Beijing 100050, Peoples R China.

年份：2009

卷号：11

期号：7

起止页码：652-657

外文期刊名：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000268666000009)】；

基金：This research was supported by the Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education. We thank Ms Wu Yan for the NMR and Mr Zeper Abliz for the EI-MS and HR-EI-MS measurements.

语种：英文

外文关键词：Pterospermum heterophyllum; Sterculiaceae; triterpenoid; naphthoquinone; cytotoxic activity

摘要：Two new triterpenoids taraxer-14-ene-1 alpha,3 beta-diol (1) and 3 beta-hydroxytaraxer-14-ene-1-one (2), together with the known triterpenes taraxerol (3), betulin (4), betulinic acid (5), sumaresinolic acid (6), and 5-hydroxy-2-methoxy-1,4-naphthoquinone (7), 5,7-dihydroxy-6,8-dimethylchromone (8), alpha-monpalmitin (9), palmitic acid (10), 6 beta-hydroxystigmast-4-en-3-one (11), beta-sitosterol (12), have been isolated from the petroleum ether fraction of the ethanolic extract of Pterospermum heterophyllum. Their structures were established by spectroscopic methods including IR, MS, 1D, and 2D NMR experiments. Compounds 1 8 were evaluated against several human cancer cell lines. Compound 1 showed in vitro selective cytotoxicity against human lung cancer cell lines (A549) with an IC50 value of 1.22 mu M. Compound 7 showed significant cytotoxicity against the A549, HCT-8, Bel7402, BGC-823, and A2780 cancer cell lines with IC50 values of 0.21, 0.55, 0.40, 0.59, and 0.34 mu M, respectively. However, the other compounds were inactive (IC50 > 10 mu M).