文献类型：期刊文献

中文题名：丹参素及其衍生物的合成

英文题名：Synthesis of danshensu and derivatives

作者：张彦文[1];冯淑华[2]

第一作者：张彦文

机构：[1]天津医科大学药学院;[2]北京联合大学生物医药系

第一机构：天津医科大学药学院,天津300070

年份：2005

卷号：11

期号：4

起止页码：522-524

中文期刊名：天津医科大学学报

外文期刊名：Journal of Tianjin Medical University

基金：天津市教委基金资助(编号:20010701)

语种：中文

中文关键词：丹参素;合成;还原反应;硼氢化钾

外文关键词：Danshengsu ; Synthesising; Reduction reaction; Potassium borohydride

摘要：目的:探讨丹参素的合成方法,并以苯基乳酸为先导化合物,通过设计、合成衍生物,对其进行结构修饰。方法:使用硼氢化钾代替锌汞齐还原羰基,通过乙酰化反应对丹参素及其衍生物进行结构修饰。结果:使用硼氢化钾将羰基还原成羟基,合成了丹参素及其衍生物的乙酰化产物,经1H-NMR证实其结构。结论:使用硼氢化钾还原羰基,产物单一,条件温和,易于控制。
Objective： To study the method of synthesising danshensu and derivatives of phenyllactic acid as the lead compound was designed and synthesized;modify on its structure. Methods： Carbonyl group was reducted with potassium borohydride in stead of zinc amalgam; the danshensu and its derivatives were acetylated. Results： Carbonyl group was reducted with potassium borohydride to hydroxyl group aeetylated danshensu and its derivatives were synthesized ; the structures of danshensu and its derivatives were confirmed by ^1H-NMR. Conclusion： The condition of reduction with potassium borohydrid is mildness and in control.