文献类型：期刊文献

英文题名：Inhibition and effect of almond hull extract on activities of α-amylase and α-glucosidase, and postprandial glucose in normal SD rats

作者：Yao, Yuyang[1];Liu, Juer[3,4];Miao, Qiming[1];Zhu, Xinyue[1];Sun, Lu[1];Hua, Wei[1];Zhang, Na[1];Huang, Guangwei[5];Ruan, Roger[3,4];Cheng, Yanling[1,3];Mi, Shengquan[1,2]

第一作者：Yao, Yuyang

通讯作者：Cheng, YL[1];Mi, SQ[1]

机构：[1]Beijing Union Univ, Coll Biochem Engn, Beijing, Peoples R China;[2]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing, Peoples R China;[3]Univ Minnesota, Ctr Biorefining, Dept Bioprod & Biosyst Engn, St Paul, MN USA;[4]Univ Minnesota, Dept Food Sci & Nutr, St Paul, MN USA;[5]Almond Board Calif, Modesto, CA USA

第一机构：北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Coll Biochem Engn, Beijing, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：2024

卷号：123

外文期刊名：JOURNAL OF FUNCTIONAL FOODS

收录：;Scopus(收录号：2-s2.0-85211057467);WOS:【SCI-EXPANDED(收录号:WOS:001377504200001)】；

基金：This research was funded by Almond Board of California and the Center for Biorefining, grant number BIO-22-01-YC and BIO-22-01-RR.

语种：英文

外文关键词：Almond hulls; In vitro and in vivo studies; Postprandial glucose

摘要：Controlling postprandial hyperglycemia is considered as a viable prophylactic treatment for type 2 diabetes mellitus. A major strategy in decreasing postprandial glucose involves inhibition of the carbohydrate-hydrolyzing enzymes, alpha-amylase and alpha-glucosidase. The aim of this study was to evaluate the hypoglycemic potential of almond hull extract in vitro and in vivo. The in vitro results showed that, among the 0 %, 30 %, 50 % and 80 % ethanol extracts of almond hull, the 50 % ethanol extracts demonstrated the most significant inhibition of digestive enzymes. With in vivo tests, the blood glucose concentration in the control rats increased sharply near the peak glucose level in 15 min, while the peak glucose level of rats loading the almond hull extract occurred in 30 min. Therefore, almond hull extract can reduce postprandial blood glucose levels and delay the time to peak by about 15 min, providing a sustained and gradual release of energy.