文献类型：期刊文献

英文题名：Effects of Eucommia ulmoides leaf extract on xanthine oxidase and chronic kidney disease induced by adenine in rats

作者：Song, Haochong[1];Ren, Wenping[2];Liu, Tingting[3];Zou, Shengcan[3];Yin, Dongli[3];Yu, Jia[2]

第一作者：Song, Haochong

通讯作者：Yu, J[1]

机构：[1]Beijing Union Univ, Coll Special Educ, Beijing, Peoples R China;[2]Qingdao Univ, Coll Life Sci, Qingdao, Peoples R China;[3]Qingdao Chenlan Pharmaceut Co Ltd, Qingdao, Peoples R China

第一机构：北京联合大学特殊教育学院

通讯机构：[1]corresponding author), Qingdao Univ, Coll Life Sci, Qingdao, Peoples R China.

年份：2024

外文期刊名：NATURAL PRODUCT RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001277285000001)】；

基金：This research was supported by Taishan Industrial Leading Talents Project-Blue Talent Special (2022).

语种：英文

外文关键词：Eucommia ulmoides leaf extract (EULE); adenine-induced chronic kidney disease rat; xanthine oxidase (XO); allopurinol; oxidative stress; inflammatory response

摘要：The aim of this study was to explore the uric acid-lowering effect and renal protective effect of Eucommia ulmoides leaf extract (EULE). The results of xanthine oxidase inhibition assay showed EULE exhibited a high inhibition rate similar to that of allopurinol, with an IC50 value of 1.53 mg/mL. A chronic kidney disease (CKD) model was established in adenine-induced rats to investigate the therapeutic effect of EULE on CKD. The results demonstrated EULE could reduce blood pressure and improve renal index. Additionally, EULE could regulate serum and urine indicators of renal function injury, and restore renal tissue morphology. Mechanistically, EULE was found to downregulate levels of malondialdehyde (MDA), tumour necrosis factor-alpha (TNF-alpha), and interleukin-1 beta (IL-1 beta), while upregulating total antioxidant capacity (T-AOC), thereby alleviating inflammatory response in rats, leading to a reduction in renal damage. the Our findings provide potential applications of EULE as a natural product for the improvement of renal injury.