文献类型：期刊文献

英文题名：Grape Seed Proanthocyanidins Extract Prevents Cisplatin-induced Cardiotoxicity in Rats

作者：Lian, Yanna[1,2];Gao, Liping[1,2];Guo, Peipei[1,2];Zhao, Yanmeng[1,2];Lin, Teryun[3]

第一作者：Lian, Yanna

通讯作者：Gao, LP[1];Gao, LP[2]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]Beijing Union Univ, Coll Arts & Sci, Beijing 100191, Peoples R China;[3]North Pk Univ, Dept Biol, Chicago, IL 60625 USA

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]corresponding author), Beijing Union Univ, Coll Arts & Sci, Beijing 100191, Peoples R China.|[114172]北京联合大学应用文理学院;[11417]北京联合大学;[1141726]北京联合大学生物化学工程学院;

年份：2016

卷号：22

期号：3

起止页码：403-408

外文期刊名：FOOD SCIENCE AND TECHNOLOGY RESEARCH

收录：;EI(收录号：20162702561481);Scopus(收录号：2-s2.0-84976519092);WOS:【SCI-EXPANDED(收录号:WOS:000376815200012)】；

基金：This work was supported by Beijing Natural Science Foundation (NO.7163211).

语种：英文

外文关键词：grape seed proanthocyanidins extract; cisplatin; cardiotoxicity; oxidative stress

摘要：Cisplatin-treated rats experienced a significant elevation of serum activities of lactate dehydrogenase (LDH), aspartate transaminase (AST), alanine transaminase (ALT) and creatine kinase (CK). These effects were accompanied by significant increases in the levels of malondialdehyde (MDA) and nitric oxide (NO), and decreases in the glutathione (GSH) content, and the activities of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) in cardiac tissues. Pathological examination revealed that cisplatin caused significant cardiac damage in rats. Grape seed proanthocyanidins extract (GSPE) administration produced amelioration in biochemical indices of cardiotoxicity, lipid peroxidation, oxidative stress, as well as histological change when compared to group cisplatin alone. GSPE were shown to be potential candidates to ameliorate cisplatin-induced cardiotoxicity.