文献类型：期刊文献

英文题名：Smoke visualization for the invasion of pollutants during door-opening process in pharmaceutical cleanrooms: Effects of initial pressure differential and airlock barriers

作者：Shao, Xiaoliang[1];Liu, Yemin[1];Hao, Yunfeng[1];Wen, Xueying[1];Li, Chunwang[2];Ma, Xiaojun[2];Wang, Huan[3];Li, Xianting[3]

第一作者：Shao, Xiaoliang

通讯作者：Ma, XJ[1]

机构：[1]Univ Sci & Technol Beijing, Sch Civil & Resource Engn, Beijing 100083, Peoples R China;[2]Beijing Union Univ, Coll Biochem Engn, Beijing 100023, Peoples R China;[3]Tsinghua Univ, Sch Architecture, Dept Bldg Sci, Beijing 100084, Peoples R China

第一机构：Univ Sci & Technol Beijing, Sch Civil & Resource Engn, Beijing 100083, Peoples R China

通讯机构：[1]corresponding author), Beijing Union Univ, Coll Biochem Engn, Beijing 100023, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：2023

卷号：279

外文期刊名：ENERGY AND BUILDINGS

收录：;EI(收录号：20230213361807);Scopus(收录号：2-s2.0-85145659570);WOS:【SCI-EXPANDED(收录号:WOS:000905608000006)】；

基金：This study is supported by the National Natural Science Founda- tion of China (Grant No. 51878043 and 51908313) , Beijing Natural Science Foundation (Grant No. 8212012) , the National Key Research and Development Program of China (Grant No. 2018YFC0705201) , Special Fund of Beijing Key Laboratory of Indoor Air Quality Evaluation and Control (Grant No. BZ0344KF21-01) , and Fundamental Research Funds for the Central Universities (Grant No. FRF-TP-20-001A3) .

语种：英文

外文关键词：Pharmaceutical cleanroom; Pressure differential; Airlock; Door operation; Smoke migration

摘要：Little research has been conducted on containing pollution invasion when the doors of pharmaceutical cleanrooms are opened. In this study, a clean pharmaceutical laboratory was built, and smoke visualization experiments were conducted. The transient effects of the initial pressure differential between rooms, airlock barrier, and time delay of airlock doors on the containment of disturbance by a normal door cycle of 4.5 s and by personnel entry were investigated. The initial pressure differentials were set from 5 to 25 Pa, and the delay time of the airlock doors was set from 6 to 36 s. The results indicated that the door operation and personnel entry caused smoke to invade the cleanroom. An increase in the pressure differential improved the containment of smoke migration. The amount of smoke invasion was lower, and the smoke was almost invisible by 18 s after the door opening at differential pressures of 20 and 25 Pa. An airlock exhibited an effective buffer effect even if the pressure differential across each airlock door was less than 5 Pa. Increasing the time delay was beneficial for eliminating migrated polluted air in the airlock. A delay time of 16 s significantly reduced the pollution for an initial pressure differential of 5 Pa across the airlock door. These findings can provide guidance for the containment of short-term disturbances in pharmaceutical cleanrooms and other controlled spaces.(c) 2022 Elsevier B.V. All rights reserved.