文献类型：期刊文献

中文题名：Preparation and Hydrophilicity of Copolymerization of Chitosan Selectively Grafted by Polyethylene Glycol

英文题名：Preparation and hydrophilicity of copolymerization of chitosan selectively grafted by polyethylene glycol

作者：Li Ruohui[1];Shan Dantong[1];Du Ying[1]

第一作者：李若慧

通讯作者：Li, RH[1]

机构：[1]Beijing Union Univ, Biochem Engn Coll, Beijing 100023, Peoples R China

第一机构：北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Biochem Engn Coll, Beijing 100023, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：2013

卷号：28

期号：2

起止页码：334-338

中文期刊名：武汉理工大学学报：材料科学英文版

外文期刊名：JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION

收录：CSTPCD;;EI(收录号：20133916791319);Scopus(收录号：2-s2.0-84884521473);WOS:【SCI-EXPANDED(收录号:WOS:000317431600024)】；

基金：Funded by the Program of Beijing Municipal Commission of Education

语种：英文

中文关键词：单甲氧基聚乙二醇;接枝共聚反应;壳聚糖;制备;六亚甲基二异氰酸酯;异氰酸酯基团;接枝共聚物;脱乙酰壳多糖

外文关键词：chitosan; polyethylene glycol; selectively graft; grafting ratio; hydrophilicity; swelling properties

摘要：Copolymerization of chitosan selectively grafted by polyethylene glycol was prepared. Chitosan was selectively grafted by monomethoxy polyethylene glycol(mPEG-OH), which contained a hydroxyl group combining with hexamethylene diisocyanate(HDI) to form a novel macromonomer namely monomethoxy polyethylene glycol isocyanate(mPEG-NCO) containing a isocyanate group with higher chemical activity in ethyl glyoxalate solution absolutely without water. The selective grafted copolymerization of Chitosan with mPEG-NCO was conducted under heterogeneous conditions as suspension in dimethylformamide. The hydrophilic copolymers of chitosan were prepared by condensation reaction of isocyanate group on mPEG-NCO with hydroxy groups on chitosan chains because amino groups on chitosan chains were protected by complexion formation with copper ions. The effect of reaction condition on the grafting extents was discussed. Swelling properties of mPEG-g-CS were researched. The graft copolymer mPEG-g-CS was characterized by the infrared spectra. The experimental result showed that the copper ions were very effective to protect amino groups from condensation reaction. The swelling degree in water increases with adding of grafting ratio. The maximum swelling degree was up to above 132% when the grafting ratio was about 270%. The graft copolymer can be soluble partially in pure water.
Copolymerization of chitosan selectively grafted by polyethylene glycol was prepared. Chitosan was selectively grafted by monomethoxy polyethylene glycol(mPEG-OH), which contained a hydroxyl group combining with hexamethylene diisocyanate(HDI) to form a novel macromonomer namely monomethoxy polyethylene glycol isocyanate(mPEG-NCO) containing a isocyanate group with higher chemical activity in ethyl glyoxalate solution absolutely without water. The selective grafted copolymerization of Chitosan with mPEG-NCO was conducted under heterogeneous conditions as suspension in dimethylformamide. The hydrophilic copolymers of chitosan were prepared by condensation reaction of isocyanate group on mPEGNCO with hydroxy groups on chitosan chains because amino groups on chitosan chains were protected by complexion formation with copper ions. The effect of reaction condition on the grafting extents was discussed. Swelling properties of mPEG-g-CS were researched. The graft copolymer mPEG-g-CS was characterized by the infrared spectra. The experimental result showed that the copper ions were very effective to protect amino groups from condensation reaction. The swelling degree in water increases with adding of grafting ratio. The maximum swelling degree was up to above 132% when the grafting ratio was about 270%. The graft copolymer can be soluble partially in pure water.