文献类型：期刊文献

英文题名：Polyhydroxylated sterols from Monascus purpureus-fermented rice

作者：Li, Jin-Jie[1];Zhong, Xiang-Jian[1];Wang, Xin[1];Yang, Xi-Miao[1];Yue, Jian-Yu[1];Zhang, Xuan[1];Liu, Jia-Chen[1];Wang, Kai-Qi[1];Shang, Xiao-Ya[1]

第一作者：李金杰

通讯作者：Shang, XY[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, 197 Beitucheng West Rd, Beijing 100191, Peoples R China

第一机构：北京联合大学生物化学工程学院|北京联合大学应用文理学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, 197 Beitucheng West Rd, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2020

卷号：154

外文期刊名：STEROIDS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000513293100011)】；

基金：The authors gratefully acknowledge the grants from the Key projects of the Beijing Natural Sciences Foundation and Beijing Municipal Education Committee (No. KZ201811417049); the Strengthening University by Talents Program of Beijing Union University (Grant No. BPHR2018AZ01); and the Scientific Research Common Program of Beijing Municipal Commission of Education (Grant No. KM201911417014).

语种：英文

外文关键词：Monascus purpureus; Steroids; Ergosterol derivatives; Cytotoxicity

摘要：Using a cell-based cytotoxicity assay, two new polyhydroxylated sterols, 16(S),22(S)-epoxy-3 beta,5 alpha,6 beta,20(R),23(R),25-hexahydroxy-7-ergostene and 3 beta,7 beta,8 alpha,25-tetrahydroxy-5,22E-ergostadiene were isolated from the ethyl acetate portion of the ethanolic extract of Monascus purpureus. Their structures were elucidated by spectroscopic analysis and in comparison with those reported in the literature. Both compounds showed cytotoxic activity against the lung adenocarcinoma (A549) with IC50 values of 12.6 and 18.5 mu M, exhibited moderate activities against human ovarian cancer (A2780), with IC50 values of 8.8 and 9.4 mu M.