文献类型：期刊文献

英文题名：Encapsulation of Antarctic krill oil in alginate-gelatin hydrogel alleviates hyperlipidemia in high-fat-diet fed rats

作者：Ma, Xuan[1];Wei, Yiming[1];He, Yi[1];Zhao, Chenrui[1];Chen, Qin[1];Liu, Bo[1];Wei, Tao[1];Yan, Wenjie[1];Wang, Feng[1,2]

第一作者：Ma, Xuan

通讯作者：Wang, F[1]

机构：[1]Beijing Union Univ, Coll Biochem Engn, Beijing 100023, Peoples R China;[2]Chinese Acad Agr Sci, Inst Food Sci & Technol, Beijing 100193, Peoples R China

第一机构：北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Coll Biochem Engn, Beijing 100023, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：2026

卷号：15

期号：1

外文期刊名：FOOD SCIENCE AND HUMAN WELLNESS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001715497800001)】；

基金：This research was funded by the National Key Research and Development Program of China (2023YFF1103804) and the Academic Research Projects of Beijing Union University (ZK20202516).

语种：英文

外文关键词：Krill oil; Microcapsule; Alginate, gelatin; High-fat diet

摘要：Krill oil is effective in reducing blood lipid levels, particularly in individuals with severe hyperlipidemia. However, poor water insolubility and stability limited its usage. This study investigated a method for encapsulating Antarctic krill oil using alginate (ALG) and gelatin (GLN) to enhance its stability and bioactivity. The encapsulation efficiency, functional group integrity, swelling rate, and lipid-lowering activity were assessed. Results indicated that the optimal encapsulation conditions were identified with an ALG:GLN ratio of 2:1 (m/m), coagulation bath of 9% CaCl2, and a nozzle size of 750 mu m, resulting in 69.34% encapsulation efficiency. Fourier-transform infrared spectroscopy confirmed successful encapsulation. The ALG-GLN shell materials enriched astaxanthin in krill oil and protected it from harsh gastric conditions, enabling targeted intestinal release. In a high-fat diet-induced rat model, krill oil microcapsules significantly reduced triglycerides (TG), total cholesterol (TC), and low-density lipoprotein-cholesterol (LDL-C) levels while increasing high-density lipoprotein-cholesterol (HDL-C) levels compared to unencapsulated krill oil. Additionally, the microcapsules elevated nitric oxide (NO) levels, enhanced superoxide dismutase (SOD) activity, and reduced malondialdehyde (MDA) levels, liver and perirenal fat weight. Therefore, encapsulating Antarctic krill oil in alginate-gelatin hydrogel offers a promising strategy for managing hyperlipidemia and associated metabolic disorders.