文献类型：期刊文献

英文题名：Effects of Tannic Acid on Gut Microbiota and Metabolomics in Mice with Type 2 Diabetes

作者：Miao, Qiming[1];Geng, Xueying[1];Yao, Yuyang[1];Yu, Congcong[1];Zhang, Jing[1,2];Bai, Haiyan[1,2];Guo, Junxia[1,2];Zhang, Yanzhen[1,2];Mi, Shengquan[1,2]

第一作者：Miao, Qiming

通讯作者：Mi, SQ[1];Mi, SQ[2]

机构：[1]Beijing Union Univ, Coll Biochem Engn, Beijing, Peoples R China;[2]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing, Peoples R China

第一机构：北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Coll Biochem Engn, Beijing, Peoples R China;[2]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing, Peoples R China.|[114172]北京联合大学应用文理学院;[11417]北京联合大学;[1141726]北京联合大学生物化学工程学院;

年份：2026

卷号：70

期号：5

外文期刊名：MOLECULAR NUTRITION & FOOD RESEARCH

收录：;Scopus(收录号：2-s2.0-105031482697);WOS:【SCI-EXPANDED(收录号:WOS:001716045700003)】；

基金：The author has nothing to report.

语种：英文

外文关键词：gut microbiota; metabolomics; tannic acid; type 2 diabetes

摘要：Tannin, a mixture of polyphenols, has been shown to possess various pharmacological activities, including antitumor, hypolipidemic, and hypoglycemic effects. Currently, tannic acid has demonstrated beneficial effects in improving the streptozotocin-induced type2 diabetes model. However, the specific mechanisms by which tannic acid lowers blood glucose through modulation of the gut microbiota and metabolomics remain to be fully elucidated. This study investigated the therapeutic effect of tannic acid from Galla Chinensis on mice with type 2 diabetes (T2D) induced by a high-fat diet (HFD) and streptozotocin (STZ). To explore the potential mechanisms, we conducted 16S diversity analysis of gut microbiota and non-targeted metabolomics analysis. Our findings demonstrate that appropriate administration of tannic acid significantly reduces fasting blood glucose levels and alleviates pathological changes in the liver and islets. The results indicate that tannic acid promotes the growth of beneficial bacteria and inhibits harmful bacteria. Furthermore, tannic acid improves diabetes and its complications mainly through glycerolphospholipid metabolism and arachidonic acid metabolism.