文献类型：期刊文献

中文题名：复方天麻制、剂镇痛的中枢和外周神经递质作用机理实验研究

英文题名：Analgesic Function Mechanism Study of Tian Ma Preparation on Central and Peripheral Nurotransmitters

作者：胡一冰[1];张元[2];鲁燕侠[3];许建阳[3];邱德文[4]

第一作者：胡一冰

机构：[1]成都大学,四川成都610106;[2]北京联合大学生物化学工程学院,北京100023;[3]武警总医院,北京100039;[4]贵阳中医学院,贵州贵阳550002

第一机构：成都大学,四川成都610106

年份：2008

卷号：19

期号：9

起止页码：2262-2263

中文期刊名：时珍国医国药

外文期刊名：Lishizhen Medicine and Materia Medica Research

收录：北大核心:【北大核心2004】；CSCD:【CSCD_E2011_2012】；

语种：中文

中文关键词：复方天麻制剂;神经递质;镇痛;小鼠

外文关键词：Tianma preparation ; Nenrotransmitter; Mice ; Analgesic

摘要：目的探讨复方天麻制剂镇痛的中枢与外周神经作用机制。方法以福氏完全佐剂制作慢性疼痛动物模型,采用高效液相电化学检测法与高效液相荧光检测法检测复方天麻制剂对中枢及外周神经递质的影响。结果复方天麻制剂使全脑5-羟色胺(5-HT)、5-羟吲哚乙酸(5-HIAA)、去甲肾上腺素(NE)含量明显上升;使血清5-HTP,5-HIAA含量降低。结论复方天麻制剂通过升高脑组织神经递质含量和降低血清神经递质含量达到镇痛作用。
Objective To discuss the analgesic function mechanism of Tian Ma Preparation on central and peripheral nurotransmitters. Methods Based on FCA induced pain model, the effect of Tian Ma Preparation on central and peripheral nurotransmitters was detected by high - performance liquid chromatography with electrochemical detector and high - performance liquid chromatog- raphy with fluorescence detector. Results Tian Ma Preparation markedly increased 5 - HT, 5 - HIAA and NE content in brain, decreased 5 - HTP and 5 - HIAA content in serum. Conclusion Tian Ma Preparation had analgesic function by markedly increasing content of 5 - HT,5 - HIAA and NE in brain, decreasing content of 5 - HTP and 5 - HIAA in serum.