文献类型：期刊文献

英文题名：Isolation rearing induces social and emotional function abnormalities and alters glutamate and neurodevelopment-related gene expression in rats

作者：Zhao, Xiaohong[2];Sun, Lei[2,4];Jia, Hongxiao[3];Meng, Qingxuan[4];Wu, Si[4];Li, Nanxin[1,4,5];He, Shuchang[4]

第一作者：赵晓红

通讯作者：Li, NX[1]

机构：[1]Yale Univ, Sch Med, Div Mol Psychiat, New Haven, CT 06508 USA;[2]Beijing Union Univ, Coll Arts & Sci, Dept Biol, Beijing 100083, Peoples R China;[3]Capital Med Univ, Beijing Anding Hosp, Beijing 100088, Peoples R China;[4]Peking Univ, Dept Psychol, Beijing 100871, Peoples R China;[5]Yale Univ, Dept Psychol, New Haven, CT 06520 USA

第一机构：Yale Univ, Sch Med, Div Mol Psychiat, New Haven, CT 06508 USA

通讯机构：[1]corresponding author), Yale Univ, Sch Med, Div Mol Psychiat, 34 Pk St, New Haven, CT 06508 USA.

年份：2009

卷号：33

期号：7

起止页码：1173-1177

外文期刊名：PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

收录：;Scopus(收录号：2-s2.0-69349091136);WOS:【SCI-EXPANDED(收录号:WOS:000270285500012)】；

基金：This project was funded by Natural Science Foundation of China (Grant No. 30870768) to S.H. and Beijing Union University "Challenge Cup" student research fund to L.S. We thank Jie Jiang, Kaiying Wang, Jinxuan Chen, and Jian Li for assistances with behavioral testing. We also sincerely thank Xiaowei Su for reading an earlier version of the manuscript.

语种：英文

外文关键词：Anxiety; Glutamate; Neurodevelopmental-related gene; Social isolation; Social recognition

摘要：Isolation rearing induces various cognitive abnormalities such as reversal learning deficits and reduced prepulse inhibition in rats. However, there are few reports in the literature on its effects on social and emotional functions. In the current study we aimed to address these issues and demonstrated that isolation rearing induced aggression and impaired social recognition, produced moderate anxiogenic effects in the elevated-plus maze, and resulted in hyperactivity in a novel open field. We also found NR2A, NR2B, PSD-95 and SAP-102 mRNA expression were significantly up-regulated in the hippocampus while NR2B was down-regulated in prefrontal cortex in response to isolation rearing. This study advances the use of social isolation as an animal model for studying etiological mechanisms of various neuropsychiatric disorders. (C) 2009 Elsevier Inc. All rights reserved.