文献类型：期刊文献

英文题名：Visible UCNPs-magnesium matrix composites for optimizing degradation and improving bone regeneration

作者：Wang, Meng[1,2];Sun, Xirao[1,2];Yang, Jingxin[3];Wang, Yanfu[4];Song, Siyu[1,2];Shi, Zheng[1,2];Sun, Danfang[1,2];Li, Dan[1,2];Chen, Jianduo[1,2];Wang, Chengyue[1,2,5]

第一作者：Wang, Meng

通讯作者：Wang, CY[1];Wang, CY[2]

机构：[1]Jinzhou Med Univ, Sch Stomatol, Jinzhou 121000, Peoples R China;[2]Jinzhou Med Univ, Stomatol Hosp, Jinzhou 121000, Peoples R China;[3]Beijing Union Univ, Coll Robot, Beijing 100000, Peoples R China;[4]China Med Univ, Sch & Hosp Sotmatol, Shenyang 110002, Peoples R China;[5]Jinzhou Med Univ, Collaborat Innovat Ctr Hlth Promot Children & Adol, Jinzhou 121000, Peoples R China

第一机构：Jinzhou Med Univ, Sch Stomatol, Jinzhou 121000, Peoples R China

通讯机构：[1]corresponding author), Jinzhou Med Univ, Collaborat Innovat Ctr Hlth Promot Children & Adol, Jinzhou 121000, Peoples R China;[2]corresponding author), Jinzhou Med Univ, Sch Stomatol, Dept Prosthodont, Jinzhou 121000, Peoples R China.

年份：2025

卷号：170

外文期刊名：BIOMATERIALS ADVANCES

收录：;EI(收录号：20250617818451);Scopus(收录号：2-s2.0-85216865333);WOS:【SCI-EXPANDED(收录号:WOS:001423923100001)】；

基金：This work was financially supported by the National Natural Science Foundation of China (62375115) , National Natural Science Foundation of China (U21A2074) , Applied Basic Research Program of Liaoning Province (2023JH2/101700071) , and the Science and Technology Innovation Team Program of Liaoning Province (LJ222410160037) .

语种：英文

外文关键词：Magnesium matrix composites; UCNPs; Degradation rate; Degradation monitoring; Osteogenic

摘要：Magnesium alloys have attracted significant interest in bone tissue engineering because of their beneficial characteristics. However, their widespread application is still hindered by rapid degradation rates and the challenges associated with real-time monitoring. Given that up-conversion nanoparticles (UCNPs) possess imaging capabilities and that nanofillers can enhance the degradation behavior of these materials, we have utilized UCNPs to develop metal matrix composites. Specifically, we employed powder metallurgy technology to prepare up-conversion nanoparticles/magnesium/zinc composites (UCNPs/Mg/Zn). We systematically studied the mechanical properties, degradation behavior, biocompatibility, osteogenic activity, and degradation monitoring of the composite. In vivo and in vitro degradation studies demonstrated that the composite containing 10 % UCNPs, 86 % Mg, and 4 % Zn (10U-Mg-4Zn) gradually degrades over time, with luminous intensity initially increasing from weak to strong before subsequently diminishing. Furthermore, compared to complexes containing 96 % Mg and 4 % Zn (Mg-4Zn), the degradation rate of the 10U-Mg-4Zn complex was significantly reduced, while cytocompatibility improved and osteogenic differentiation of mouse embryonic osteoblasts (MC3T3-E1) was markedly enhanced. Therefore, the 10U-Mg-4Zn composite not only demonstrates good degradation performance and supports bone tissue regeneration but also facilitates the monitoring of material degradation, thereby providing a novel method for material evaluation and a fresh perspective for developing new magnesium matrix composites.