文献类型：会议论文

英文题名：Multiscale study on hemodynamics in patient-specific thoracic aortic coarctation

作者：Zhao, Xi[1]; Liu, Youjun[1]; Ding, Jinli[1]; Zhang, Mingzi[2]; Fu, Wenyu[3,4]; Bai, Fan[1]; Ren, Xiaochen[1]; Qiao, Aike[1]

第一作者：Zhao, Xi

通讯作者：Qiao, A.

机构：[1] College of Life Science and Bio-engineering, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing, 100124, China; [2] Graduate School of Engineering, Tohoku University, Ohta Laboratory, 2-1-1 Katahira, Aoba-ku Sendai Miyagi, 980-8577, Japan; [3] College of Mechanical and Electrical Engineering, Beijing Union University, Beijing 100020, China; [4] College of Architecture and Civil Engineering, Beijing University of Technology, Beijing 100124, China

第一机构：College of Life Science and Bio-engineering, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing, 100124, China

通讯机构：[1]College of Life Science and Bio-engineering, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing, 100124, China

会议论文集：Statistical Atlases and Computational Models of the Heart: Imaging and Modelling Challenges - 4th International Workshop, STACOM 2013, Held in Conjunction with MICCAI 2013, Revised Selected Papers

会议日期：September 26, 2013 - September 26, 2013

会议地点：Nagoya, Japan

语种：英文

外文关键词：Blood vessels - Computation theory - Computational fluid dynamics - Computational methods - Heart - Hemodynamics - Life cycle - Pressure gradient

摘要：In this challenge, we intended to mimic the patient's cardiovascular system by using 0D-3D connected multiscale model. The purpose of the multiscale analysis is to find out the appropriate boundary conditions of the innominate artery (IA), left common carotid artery (LCA) and left subclavian artery (LSA) in the local 3D computational fluid dynamics simulation. Firstly, a lumped parameter model(LPM) of the patient's circulatory system was established which could mimic both the rest and stress conditions by adjusting parameters like elastance function of the heart and the peripheral resistance, since that administering is oprenaline leads to the patient's heart beat rate and peripheral resistance changes. Secondly, the values of parameters in the LPM were slightly revised to match the following conditions: 1. provided pressure and flow rate curves, 2. provided blood distribution ratio of the AcsAo, IA, LCA and LSA. Finally, we got the outlet conditions of the IA, LCA and LSA, and then connecting the 0D model and the 3D model at each time step. As the results, we got the streamlines, pressure drop through the coarctation, pressure gradient, and some other parameters by coupled multiscale simuation. ? Springer-Verlag Berlin Heidelberg 2014.