文献类型：期刊文献

英文题名：Four new taraxastane-type triterpenoic acids from Cirsium setosum

作者：Luan, Na[1];Wei, Wen-Di[1];Wang, Ali[1];Wu, Xiu-Li[2];Qi, Yan[3];Li, Jin-Jie[1];Zheng, Jian-Quan[1];Shang, Xiao-Ya[1]

第一作者：栾娜

通讯作者：Shang, XY[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]Ningxia Med Univ, Coll Pharm, Yinchuan 750004, Peoples R China;[3]Beijing Municipal Bur City Adm & Law Enforcement, Beijing 101500, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2016

卷号：18

期号：11

起止页码：1015-1023

外文期刊名：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000384689900001)】；

基金：This work was financially supported by the Beijing Natural Sciences Foundation [grant number 7142028]; National Natural Sciences Foundation of China (NNSFC) [grant number 31171669]; Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University [Zk60201601].

语种：英文

外文关键词：Compositae; Cirsium setosum; taraxastane-type triterpenoids acids; absolute configuration; cytotoxic activities

摘要：Four new taraxastane-type triterpenoids acids 3,22-dihydroxy-20-taraxasten-30-oic acid (1), 3-hydroxy-22-oxo-20-taraxasten-30-oic acid (2), 3-oxo-22-hydroxy-20- taraxasten-30-oic acid (3), and 3,19-dihydroxy-20-taraxasten-30-oic acid (4) were isolated and characterized from Cirsium setosum (Willd.) MB. Their structures were determined by the combination of 1D and 2D NMR experiments (H-1-(HCOSY)-H-1, HSQC, HMBC and ROESY) and mass spectrometry. Compound 2 exhibited potent selective cytotoxicity against human ovarian cancer cell line A2780 with an IC50 value of 3.9M.