文献类型：期刊文献

英文题名：Prospective study of probiotic supplementation results in immune stimulation and improvement of upper respiratory infection rate

作者：Zhang, Hong[1];Yeh, Chiajung[2];Jin, Zonglian[3];Ding, Liwei[2];Liu, Bryan Y.[5];Zhang, Li[4];Dannelly, H. Kathleen[5]

第一作者：Zhang, Hong

通讯作者：Dannelly, HK[1]

机构：[1]Capital Med Univ, Beijing Chao Yang Hosp, 8 Gongti South Rd, Beijing 10020, Peoples R China;[2]Hangzhou Weiquan Foods Co, LTD R&D Ctr, 1688 Wu Zhong Rd, Shanghai 201100, Peoples R China;[3]Beijing Union Univ, Coll Appl Arts & Sci, 197 Bei Tu Cheng W Rd, Beijing 100108, Peoples R China;[4]SPRIM China, 100 Zunyi Rd, Shanghai 200336, Peoples R China;[5]Indiana State Univ, Dept Biol, 600 Chestnut St, Terre Haute, IN 47809 USA

第一机构：Capital Med Univ, Beijing Chao Yang Hosp, 8 Gongti South Rd, Beijing 10020, Peoples R China

通讯机构：[1]corresponding author), Indiana State Univ, Dept Biol, 600 Chestnut St, Terre Haute, IN 47809 USA.

年份：2018

卷号：3

期号：2

起止页码：113-120

外文期刊名：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY

收录：;Scopus(收录号：2-s2.0-85046585657);WOS:【SCI-EXPANDED(收录号:WOS:000441188400006)】；

基金：Funding for this study was received from Hangzhou Weiquan Foods Co., LTD R&D Center, 1688 Wu Zhong Road, Minhang District, Shanghai, China 201100.

语种：英文

外文关键词：Probiotics; Upper respiratory infections; Human microbiota; IFN-gamma; sIgA

摘要：The human gut microbiota is an important environmental factor for human health with evolutionarily conserved roles in immunity, metabolism, development, and behavior of the host. Probiotic organisms are claimed to offer several functional properties including stimulation of immune system. The purpose of this study is to investigate the effects of a probiotic supplementation on adult volunteers who have contracted the common cold four or more times in the past year. This study is a single center, double-blind, randomized, controlled, prospective trial. Subjects received a probiotic drink containing Lactobacillus paracasei (at least 3 x 10(7) colony forming units (CFU) ml(-1)), Lactobacillus casei 431 (R) (at least 3 x 10(7) CFU ml(-1)) and Lactobacillus fermentium PCC (R) (at least 3 x 10(6) CFU ml(-1)) or an identical placebo without probiotics for a 12-week study period. The consumption of probiotics significantly reduced the incidence of upper respiratory infection (p < 0.023) and flu-like symptoms with an oral temperature higher than 38 degrees C (p<0.034) as compared to the placebo group. Subjects that consumed probiotics demonstrated a significantly higher level of IFN-gamma in the serum (p < 0.001) and sIgA in the gut (p < 0.010) as compared to the placebo group and a significant higher level of serum IFN-gamma (p < 0.001) and gut sIgA (p < 0.001) as compared to their baseline test results. In contrast, there were no significant differences in the serum IL-4, IL-10, IgA, IgG or IgM between the probiotics and the placebo groups. Results of this study demonstrated that probiotics were safe and effective for fighting the common cold and influenza-like respiratory infections by boosting the immune system. (C) 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co.