文献类型：期刊文献

英文题名：Research on the health effects of Cistanches from the perspective of the gut-metabolism-organ axis

作者：Zhang, Shaoshi[1,2]; Yang, Tianyu[1]; Lu, Jiamin[1]; Zhao, Jian[1,2]; Guo, Yu[1,2]; Yan, Wenjie[1,2]

第一作者：Zhang, Shaoshi

机构：[1] Beijing Key Laboratory of Bioactive Substances and Functional Foods, College of Biochemical Engineering, Beijing Union University, Beijing, 100023, China; [2] Functional Food Testing Center, College of Applied Arts and Sciences, Beijing Union University, Beijing, 100191, China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]Beijing Key Laboratory of Bioactive Substances and Functional Foods, College of Biochemical Engineering, Beijing Union University, Beijing, 100023, China|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2026

卷号：172

外文期刊名：Trends in Food Science and Technology

收录：EI(收录号：20261420437830);Scopus(收录号：2-s2.0-105034729404)

语种：英文

外文关键词：Agriculture - Amino acids - Biochemistry - Biological organs - Body fluids - Chains - Metabolism - Metabolites - Self assembly

摘要：Background: Cistanches, as an important characteristic agricultural product and food-medicine dual-purpose substance in the northwest of China, has great potential for development that needs to be unlocked through in-depth research on its mechanism of action. Traditional studies have mostly focused on the effects of Cistanches on a single organ or physiological system. However, research based on the "biological axis" perspective can help comprehensively reveal its multi-target and cross-system regulatory mechanisms, thereby highlighting the unique advantages of food-medicine dual-purpose substances in regulating the body. Research scope and methods: This article takes the "gut-metabolism-organ axis" as the core perspective, systematically sorting out the differences in bioactive substances and in vivo metabolites of different varieties of Cistanches, and analyzing the intervention pathways of Cistanches on health issues of the brain, kidneys, liver, bones, etc. Key findings and conclusions: Phenylethanoid glycosides and polysaccharides in Cistanche deserticola synergistically regulate intestinal metabolic pathways, including short-chain fatty acids, bile acids, amino acids, lipids, and vitamins, thereby improving gut health and associated organ axes (gut-brain, gut-liver, gut-kidney, gut-bone). Short-chain fatty acid and amino acid metabolism represent the central pathways involved. The synergistic interactions between active components vary across species due to differences in constituent accumulation and content profiles. Moreover, material science approaches such as self-assembly can enhance the bioavailability and targeting of Cistanche-derived bioactive compounds. The above discoveries have established a complete research framework for Cistanche from its resource characteristics to functional applications, facilitating its transformation into broader health values under the context of the "Big Food View". ? 2026 Elsevier Ltd