文献类型：期刊文献

英文题名：The association of dietary choline intakes with cognitive function among the older people in underdeveloped regions: findings from the NCDFaC study

作者：Liu, Dan[1];Niu, Yingying[2];Yan, Haoyu[2];Li, Chengping[2];Chen, Lianhong[2];Li, Chenglian[3];Dong, Kui[4];Li, Zhihao[1];Zhang, Jian[5];Wang, Zhuoqun[6];Song, Pengkun[5];Zhao, Yanfang[6];Zhai, Yi[7];Zhang, Mei[6];Pang, Shaojie[8];Mi, Shengquan[9];Liang, Xiaofeng[2,10,11];Song, Shuang[5];Yin, Zhaoxue[12,13];Zhao, Wenhua[5]

第一作者：Liu, Dan

通讯作者：Zhao, WH[1];Yin, ZX[2]

机构：[1]Southern Med Univ, Sch Publ Hlth, Dept Epidemiol, Guangzhou, Guangdong, Peoples R China;[2]Jinan Univ, Sch Med, Dept Publ Hlth & Prevent Med, Guangzhou, Peoples R China;[3]Shanxi Prov Ctr Dis Control & Prevent, Dept Chron Dis & Student Hlth, Taiyuan, Peoples R China;[4]Linyi Ctr Dis Control & Prevent, 1159 Shuangtanan Rd, Linyi 044100, Peoples R China;[5]Chinese Ctr Dis Control & Prevent, Natl Inst Nutr & Hlth, Beijing 100050, Peoples R China;[6]CDC, Natl Ctr Chron & Noncommunicable Dis Control & Pre, Beijing, Peoples R China;[7]Capital Med Univ, Beijing Tiantan Hosp, Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China;[8]Acad Natl Food & Strateg Reserv Adm, Inst Grain Qual & Nutr Res, Beijing, Peoples R China;[9]Beijing Union Univ, Coll Biochem Engn, 18 Zone Three, Beijing, Peoples R China;[10]Jinan Univ, Dis Control & Prevent Inst, Guangzhou, Peoples R China;[11]Jinan Univ, Lab Viral Pathogenesis & Infect Prevent & Control, Minist Educ, Guangzhou, Peoples R China;[12]Chinese Ctr Dis Control & Prevent, Off Epidemiol, Beijing, Peoples R China;[13]Chinese Ctr Dis Control & Prevent, Div Noncommunicable Dis Control & Ageing Hlth, Beijing, Peoples R China

第一机构：Southern Med Univ, Sch Publ Hlth, Dept Epidemiol, Guangzhou, Guangdong, Peoples R China

通讯机构：[1]corresponding author), Chinese Ctr Dis Control & Prevent, Natl Inst Nutr & Hlth, Beijing 100050, Peoples R China;[2]corresponding author), Chinese Ctr Dis Control & Prevent, Off Epidemiol, Beijing, Peoples R China.

年份：2025

卷号：24

期号：1

外文期刊名：NUTRITION JOURNAL

收录：;Scopus(收录号：2-s2.0-105017594661);WOS:【SCI-EXPANDED(收录号:WOS:001586094400001)】；

基金：This work was supported by the National Natural Science Foundation of China (82003443, 82204044, and 82204115), the Construction of High-level University of Guangdong (G624330422), Young Elite Scientists Sponsorship Program by CAST (2019QNRC001), and the Guangzhou Science and Technology Project (2023A04J0637). The funders played no role in the study design or implementation; data collection, management, analysis or interpretation; manuscript preparation, review or approval, or the decision to submit the manuscriptfor publication.

语种：英文

外文关键词：Dietary choline; Cognitive function; Older people; Underdeveloped regions

摘要：ObjectivesWe aimed to investigate the associations between dietary choline, its subtypes, and cognitive function in older adults from underdeveloped regions of China, using data from the Nutrition and Chronic Disease Family Cohort (NCDFaC) study.MethodsThis cross-sectional study included 1 522 older adults aged 60 and over. Dietary choline intakes were assessed using a food frequency questionnaire, and cognitive function was evaluated with the Mini-Mental State Examination (MMSE). The associations between choline intake and mild cognitive impairment (MCI) were analyzed using logistic regression models, restricted cubic splines and propensity score matching (PSM).ResultAmong the 1 522 participants, 292 (19.2%) were diagnosed with MCI. Compared to those in the lowest quartile of total choline intake, participants in the 2nd quartile (169.0 mg/[1000 kcal*d]) had lower odds of MCI, with an OR (95% CI) of 0.63 (0.42, 0.94). Similarly, participants in the 2nd (116.0 mg/[1000 kcal*d]) and 3rd (148.0 mg/[1000 kcal*d]) quartiles of phosphatidylcholine intake had reduced odds of MCI, with ORs (95% CI) of 0.59 (0.39, 0.88) and 0.60 (0.40, 0.91), respectively. For free choline intake, the highest quartile (74.2 mg/[1000 kcal*d]) was associated with an OR (95% CI) of 0.55 (0.35, 0.86). After PSM, higher intakes of total choline and phosphatidylcholine remained associated with lower odds of MCI.ConclusionModerate to high dietary intakes of total choline, phosphatidylcholine, and free choline may be associated with lower odds of MCI among older adults in underdeveloped regions.