文献类型：期刊文献

英文题名：An integrated exposure assessment of phthalates for the general population in China based on both exposure scenario and biomonitoring estimation approaches

作者：Cao, Yan[1];Liu, Jianguo[1];Liu, Yang[2];Wang, Jie[1];Hao, Xuewen[1]

第一作者：Cao, Yan

通讯作者：Liu, JG[1]

机构：[1]Peking Univ, Coll Environm Sci & Engn, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100871, Peoples R China;[2]Beijing Union Univ, Dept Food Sci, Coll Appl Arts & Sci, Beijing 100191, Peoples R China

第一机构：Peking Univ, Coll Environm Sci & Engn, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100871, Peoples R China

通讯机构：[1]corresponding author), Peking Univ, Coll Environm Sci & Engn, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100871, Peoples R China.

年份：2016

卷号：74

起止页码：34-41

外文期刊名：REGULATORY TOXICOLOGY AND PHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-84949548590);WOS:【SCI-EXPANDED(收录号:WOS:000368555000005)】；

基金：We thank for the support from the State Key Joint Laboratory of Environment Simulation and Pollution Control (Peking University, No. 13Z04ESPCP) and the support from the National Science Foundation of China (No. 21206011); and The Importation and Development of High-Caliber Talents Project of Beijing Municipal Institutions, The National Basic Research Program of China (No. IDHT201304084).

语种：英文

外文关键词：Phthalate; Exposure assessment; Exposure scenario approach; Biomonitoring estimation approach

摘要：The representativeness of available studies on integrated exposure assessment of phthalates for the general population in China is lacking. Based on an exhaustive review of the extensive monitoring data available for China, this study presents a large-scale estimation of exposure levels to three typical phthalates, di(2-ethylhexyl) phthalate (DEHP), di-n-butyl phthalate (DBP) and diisobutyl phthalate (DiBP), by applying both exposure scenario and biomonitoring estimation approaches. The respective median exposure levels from the exposure scenario and biomonitoring estimation approaches were 3.80, 3.02 and 1.00 mu g/kg bw/day and 3.38, 3.21 and 3.32 mu g/kg bw/day for DEHP, DBP and DiBP, which are acceptable levels of exposure with respect to current international guidelines. Evaluation results from the two approaches showed both similarities and differences among the different phthalates, making the exposure assessment comparable and more comprehensive. In terms of sources of exposure, food intake was the largest contributor, while indoor air exposure had greater contribution to the estimated daily intakes (EDIs) of DiBP than that of the other phthalates. Moreover, more attention should be paid to the higher exposure levels of phthalates in several intensively industrialized and urbanized areas, and the causes of the different exposure levels in the different regions need to be further explored. (C) 2015 Elsevier Inc. All rights reserved.