文献类型：期刊文献

英文题名：Air-coupled micro-disk resonator for robust reproducible sensing of trace phosphate ions in the tap water and biological samples

作者：Li, Houchang[1,2]; Liu, Bin[3]; Liu, Juan[3]; Li, Zefeng[2]; Gao, Yuze[4]; Ma, Haili[5]; Pu, Shengli[6]; Rao, Lan[2]; Zhou, Xian[1]; Yuan, Jinhui[1,2]; Farrell, Gerald[7]; Wu, Qiang[5]

第一作者：Li, Houchang

机构：[1] School of Computer and Communication Engineering, University of Science & Technology Beijing, Beijing, 100083, China; [2] State Key Laboratory of Information Photonics and Optical Communications, Beijing University of Posts and Telecommunications, Beijing, 100876, China; [3] Key Laboratory of Optoelectronic Information Science and Technology of Jiangxi Province, NanchangHangkong University, Nanchang, 330063, China; [4] School of Tourism, Beijing Union University, Beijing, 100101, China; [5] Faculty of Engineering and Environment, Northumbria University, Newcastle upon Tyne, NE18ST, United Kingdom; [6] College of Science, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, Shanghai, 200093, China; [7] Photonics Research Centre, School of Electrical and Electronic Engineering, City Campus, Technological University Dublin, Dublin, Ireland

第一机构：School of Computer and Communication Engineering, University of Science & Technology Beijing, Beijing, 100083, China

年份：2025

外文期刊名：SSRN

收录：EI(收录号：20250520071)

语种：英文

外文关键词：Fluorine compounds - Graphene - Ions - Magnesium compounds - Microresonators - Optical resonators - Precision engineering - Trace analysis - Whispering gallery modes

摘要：A micro-disk resonator (MDR) sensor has been developed and rigorously characterized for the rapid and robust detection of ultra-trace phosphate (Pi) ions in both tap water and complex biological matrices. Operating in whispering gallery mode, the MDR is precision-engineered from a high-purity magnesium fluoride (MgF2) crystal by ultra-precision machining to achieve nanometre-scale surface smoothness. Notably, the device has its coupling region in air and its sensing region immersed in liquid, resulting in high-quality factor performance and enhanced system stability, a significant improvement over conventional resonator architectures where the coupling and sensing region are both immersed in liquid. The surface of the MDR is functionalized with ferritin immobilized via graphene oxide nanoparticles, enabling highly specific and efficient recognition of Pi ions. The sensor exhibits a wide linear dynamic detection range from 5×10-6 to 1×10-2 mg/L, with a detection limit as low as 1.37×10-6 mg/L, significantly surpassing the sensitivity of existing Pi ion detection technologies. The assay can be completed within 10 minutes and possesses high selectivity in the presence of competing anions. The sensor was applied to real samples including tap water and biological fluids, with spiked recovery rates ranging from 96% to 104%, demonstrating its practicality. ? 2025, The Authors. All rights reserved.