文献类型：期刊文献

中文题名：低盐红方腐乳对高脂血症大鼠血脂、氧化应激和肠道微生物多样性的影响

英文题名：Effects of Low-salt Red Sufu on Blood Lipids,Oxidative Stress and Intestinal Microbial Diversity in Hyperlipidemic Rats

作者：张依潘[1];魏涛[1];化清莹[1];葛绍捷[1];季晨曦[1];刘倩[1,2]

第一作者：张依潘

机构：[1]北京联合大学生物化学工程学院,北京100023;[2]北京联合大学生物活性物质与功能食品北京市重点实验室,北京100191

第一机构：北京联合大学生物化学工程学院

年份：2026

卷号：34

期号：3

起止页码：209-219

中文期刊名：粮油食品科技

外文期刊名：Science and Technology of Cereals,Oils and Foods

收录：;北大核心:【北大核心2023】；

基金：北京联合大学科研项目“欧李康普茶中酚类化合物的组成及生物可利用度研究”(ZK10202204);河南省重大科技专项“豫产大宗中药材深度开发、产品创制与产业化”(231100310200)。

语种：中文

中文关键词：低盐红方腐乳;高脂血症;降血脂;氧化应激;肠道菌群

外文关键词：low-salt red sufu;hyperlipidemia;lipid-lowering effect;oxidative stress;gut microbiota

摘要：为探究低盐红方腐乳(LRS)对血脂、氧化应激和肠道微生物多样性的影响,将40只雄性SD大鼠随机分为正常对照组(NC)、高脂饮食模型组(HF)、低盐红方腐乳低剂量组(LRS-L)和高剂量组(LRS-H),每组10只。通过高脂饮食建立高脂血症模型,连续灌胃7周后测定体重和脏器指数,检测血清脂质、氧化应激和炎症因子水平,观察肝脏病理变化,分析肠道菌群结构。结果表明,与HF组相比,LRS-H和LRS-L组血清总胆固醇(CHO)水平显著降低,血清超氧化物歧化酶(SOD)、过氧化氢酶(CAT)和谷胱甘肽过氧化物酶(GSH-Px)含量显著提高,丙二醛(MDA)水平显著降低,同时LRS-H组中肿瘤坏死因子(TNF-α)和白细胞介素-6(IL-6)水平显著降低。肝脏HE染色显示低盐红方腐乳可有效减轻肝细胞脂肪变性,改善肝脏结构。肠道菌群分析表明低盐红方腐乳可促进短链脂肪酸产生菌增殖,抑制潜在致病菌丰度,调节肠道微生态。研究表明,低盐红方腐乳具有显著的降脂、抗氧化、抗炎及调节肠道菌群作用,具有作为功能性食品调节高脂血症的潜力。
To investigate the effects of low-salt red sufu(LRS)on blood lipids,oxidative stress and intestinal microbial diversity,40 male Sprague-Dawley(SD)rats were randomly divided into four groups with 10 rats in each group,hereinafter referred as the normal control group(NC),the high-fat diet model group(HF),the low-salt red sufu low-dose group(LRS-L)and the low-salt red sufu high-dose group(LRS-H).A hyperlipidemia model was then established via high-fat diet feeding.After a consecutive 7-week-long intragastric administration,several parameters of the rats including the body weight,visceral index,the serum levels of lipids,oxidative stress markers,inflammatory factors,the pathological changes of the liver and the intestinal flora structure was observed and analyzed.The results showed that,compared with the HF group,the LRS-H and LRS-L groups exhibited significantly decreased serum total cholesterol(CHO)levels,significantly increased activities of serum superoxide dismutase(SOD),catalase(CAT),and glutathione peroxidase(GSH-Px),and significantly reduced malondialdehyde(MDA)levels.Meanwhile,the serum levels of tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the LRS-H group were remarkably reduced.Hematoxylin-eosin(HE)staining of liver tissues demonstrated the fact that LRS could effectively alleviate hepatocellular steatosis and improve liver tissue structure.Besides,analysis of intestinal flora also indicated that LRS promoted the proliferation of short-chain fatty acid-producing bacteria,inhibited the abundance of potential pathogenic bacteria,and regulated the intestinal microecology.In conclusion,LRS exerts significant lipid-lowering,antioxidant,anti-inflammatory and intestinal flora-regulating effects,which provides experimental evidence for its application as a functional food in the prevention and treatment of hyperlipidemia.