文献类型：期刊文献

英文题名：Mangiferin Alleviates Postpartum Depression-Like Behaviors by Inhibiting MAPK Signaling in Microglia

作者：Yan, Meichen[1];Bo, Xuena[1];Zhang, Xinchao[1];Zhang, Jingdan[1];Liao, Yajin[1];Zhang, Haiyan[2];Cheng, Yong[1];Guo, Junxia[3];Cheng, Jinbo[1,4]

第一作者：Yan, Meichen

通讯作者：Cheng, JB[1];Guo, JX[2];Cheng, JB[3]

机构：[1]Minzu Univ China, Coll Life & Environm Sci, Ctr Translat Neurosci, Beijing, Peoples R China;[2]Jiangxi Univ Tradit Chinese Med, Key Lab Modern Preparat TCM, Minist Educ, Nanchang, Peoples R China;[3]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing, Peoples R China;[4]Beijing Inst Basic Med Sci, Brain Sci Ctr, Beijing, Peoples R China

第一机构：Minzu Univ China, Coll Life & Environm Sci, Ctr Translat Neurosci, Beijing, Peoples R China

通讯机构：[1]corresponding author), Minzu Univ China, Coll Life & Environm Sci, Ctr Translat Neurosci, Beijing, Peoples R China;[2]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing, Peoples R China;[3]corresponding author), Beijing Inst Basic Med Sci, Brain Sci Ctr, Beijing, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2022

卷号：13

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-85132892797);WOS:【SCI-EXPANDED(收录号:WOS:000812825000001)】；

基金：This work was supported by grants from the National Nature Science Foundation of China (Grant No. 81870839 and No. 82071218) and the open fund of the Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine (TCM-201915).

语种：英文

外文关键词：postpartum depression; mangiferin; microglia; neuroinflammation; MAPK signaling

摘要：Postpartum depression (PPD), a severe mental health disorder, is closely associated with decreased gonadal hormone levels during the postpartum period. Mangiferin (MGF) possesses a wide range of pharmacological activities, including anti-inflammation. Growing evidence has suggested that neuroinflammation is involved in the development of depression. However, the role of MGF in the development of PPD is largely unknown. In the present study, by establishing a hormone-simulated pregnancy PPD mouse model, we found that the administration of MGF significantly alleviated PPD-like behaviors. Mechanistically, MGF treatment inhibited microglial activation and neuroinflammation. Moreover, we found that MGF treatment inhibited mitogen-activated protein kinase (MAPK) signaling in vivo and in vitro. Together, these results highlight an important role of MGF in microglial activation and thus give insights into the potential therapeutic strategy for PPD treatment.