文献类型：期刊文献

中文题名：骨关节炎动物模型建立及在功能食品研究中的应用

英文题名：Establishment of an animal model of osteoarthritis and its application in functional food research

作者：陈世杰[1];劳文艳[1,2];周艳丽[1];李艳梅[3];赵晓红[1,2]

第一作者：陈世杰

机构：[1]北京联合大学应用文理学院生物活性物质与功能食品北京市重点实验室;[2]北京联合大学功能食品科学技术研究院;[3]北京绿色金可生物技术股份有限公司

第一机构：北京联合大学应用文理学院

年份：2017

卷号：21

期号：28

起止页码：4536-4542

中文期刊名：中国组织工程研究

外文期刊名：Chinese Journal of Tissue Engineering Research

收录：CSTPCD;;北大核心:【北大核心2014】；

基金：北京联合大学生物活性物质与功能食品北京市重点实验室开放课题(Zk70201501)~~

语种：中文

中文关键词：组织构建;骨组织工程;骨关节炎;动物模型建立;生物活性物质;功能食品

外文关键词：Osteoarthritis; Models, Animal; Tissue Engineering

摘要：背景:骨关节炎的发病机制尚不明确,临床缺乏根治措施,研究重点大部分都放在减轻疼痛、改善关节功能等方面。建立动物模型是研究骨关节炎病理机制、预防及治疗的重要手段,也是预防和改善骨关节炎保健食品新功能开发研究的必要方式。目的:综述骨关节炎动物模型的建立及其在预防骨关节炎功能食品研究中的应用,以期为正确合理的选择骨关节炎动物模型及生物活性物质筛选试验提供科学依据。方法:检索至2016年5月为止PubMed数据(http://www.ncbi.nlm.nih.gov/PubMed)及CNKI中国期刊全文数据库(http://www.cnki.net/)有关建立节炎动物模型的文献,英文检索词为"osteoarthritis,animal model",中文检索词为"骨关节炎,动物模型"。排除重复性研究,共检索到157篇相关文献,59篇文献符合纳入标准。结果与结论:(1)骨关节炎动物模型的建立方法多种多样,各种造模方法各有优缺点,应用范围也不相同;(2)因此需要选择和建立合适的骨关节炎动物模型,通过动物实验深入探索骨关节炎的发病机制,筛选出更多可以预防和改善骨关节炎的有效物质,并开发出相应的功能性食品,以减轻患者的痛苦并提高生活质量,具有十分重要的意义。
BACKGROUND:Unclear pathogenesis of osteoarthritis results in a lack of radical therapy.The current studies mainly focus on pain relief and joint function improvement.Establishing an animal model is helpful to explore the pathogenesis,prevention and treatment of osteoarthritis,and also contributes to develop health food with new functions used for preventing and improving osteoarthritis.OBJECTIVE:To overview the establishment of the osteoarthritic animal model and its application in functional food research,thereby providing scientific basis for reasonable selection of osteoarthritic animal models and screening tests of bioactive substances.METHODS:CNKI and PubMed databases were retrieved for the articles related to animal model establishment published before May,2016,using the keywords of“osteoarthritis,animal model”in Chinese and English,respectively.Totally157articles were searched initially after repetitive ones excluded,and then59eligible articles were included.RESULTS AND CONCLUSION:Animal models of osteoarthritis are established in a variety of ways,and have their own advantages and disadvantages,with different application scopes.Therefore,we need select and establish appropriate animal models used for studying the pathogenesis of osteoarthritis and screening more specific and effective substances that can prevent and improve osteoarthritis.Additionally,it is of great significance for further developing the corresponding functional health food to alleviate the patients’pain and improve their quality of life.